Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 893141..893918 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag J1G50_RS04600 Protein ID WP_005710654.1
Coordinates 893141..893641 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag J1G50_RS04605 Protein ID WP_005710653.1
Coordinates 893631..893918 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS04565 888266..888421 - 156 WP_005710668.1 YoaH family protein -
J1G50_RS04570 888439..889167 - 729 WP_021115014.1 tRNA pseudouridine(65) synthase TruC -
J1G50_RS04575 889164..889478 - 315 WP_005710664.1 YqcC family protein -
J1G50_RS04580 889520..890434 - 915 WP_082259327.1 N-acetylmuramic acid 6-phosphate etherase -
J1G50_RS04585 890446..891561 - 1116 WP_035519838.1 anhydro-N-acetylmuramic acid kinase -
J1G50_RS04590 891716..892051 - 336 WP_010786648.1 outer membrane protein assembly factor BamE -
J1G50_RS04595 892112..893113 - 1002 WP_005710656.1 nucleoid-associated protein YejK -
J1G50_RS04600 893141..893641 - 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
J1G50_RS04605 893631..893918 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
J1G50_RS04610 894064..894453 + 390 WP_035519839.1 RidA family protein -
J1G50_RS04615 894457..895194 + 738 WP_044009509.1 peptidoglycan editing factor PgeF -
J1G50_RS04620 895369..896946 + 1578 WP_026916904.1 FAD-binding protein -
J1G50_RS04625 897051..897551 + 501 WP_016527798.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T196467 WP_005710654.1 NZ_CP071489:c893641-893141 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T196467 NZ_CP095137:c46359-45982 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT196467 WP_005710653.1 NZ_CP071489:c893918-893631 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT196467 NZ_CP095137:c46780-46406 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References