Detailed information of TA system TA196467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 893141..893918
• Replicon: chromosome
• Accession: NZ_CP071489
• Organism: Glaesserella parasuis strain YHP1815

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: B8F4U7
• Locus tag: J1G50_RS04600
• Protein ID: WP_005710654.1
• Coordinates: 893141..893641 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: J1G50_RS04605
• Protein ID: WP_005710653.1
• Coordinates: 893631..893918 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1G50_RS04565	888266..888421	-	156	WP_005710668.1	YoaH family protein	-
J1G50_RS04570	888439..889167	-	729	WP_021115014.1	tRNA pseudouridine(65) synthase TruC	-
J1G50_RS04575	889164..889478	-	315	WP_005710664.1	YqcC family protein	-
J1G50_RS04580	889520..890434	-	915	WP_082259327.1	N-acetylmuramic acid 6-phosphate etherase	-
J1G50_RS04585	890446..891561	-	1116	WP_035519838.1	anhydro-N-acetylmuramic acid kinase	-
J1G50_RS04590	891716..892051	-	336	WP_010786648.1	outer membrane protein assembly factor BamE	-
J1G50_RS04595	892112..893113	-	1002	WP_005710656.1	nucleoid-associated protein YejK	-
J1G50_RS04600	893141..893641	-	501	WP_005710654.1	GNAT family N-acetyltransferase	Toxin
J1G50_RS04605	893631..893918	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
J1G50_RS04610	894064..894453	+	390	WP_035519839.1	RidA family protein	-
J1G50_RS04615	894457..895194	+	738	WP_044009509.1	peptidoglycan editing factor PgeF	-
J1G50_RS04620	895369..896946	+	1578	WP_026916904.1	FAD-binding protein	-
J1G50_RS04625	897051..897551	+	501	WP_016527798.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19184.39 Da
• Isoelectric Point: 9.3198

>T196467 WP_005710654.1 NZ_CP071489:c893641-893141 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T196467 NZ_CP095137:c46359-45982 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT196467 WP_005710653.1 NZ_CP071489:c893918-893631 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT196467 NZ_CP095137:c46780-46406 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A836YZP3

Antitoxin

• AlphaFold DB: U4SPD7