Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 468708..469321 | Replicon | chromosome |
| Accession | NZ_CP071489 | ||
| Organism | Glaesserella parasuis strain YHP1815 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | J1G50_RS02530 | Protein ID | WP_200859958.1 |
| Coordinates | 468708..468875 (+) | Length | 56 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | U4SMI8 |
| Locus tag | J1G50_RS02535 | Protein ID | WP_021110735.1 |
| Coordinates | 468914..469321 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J1G50_RS02470 | 463713..464228 | - | 516 | WP_160421849.1 | terminase small subunit | - |
| J1G50_RS02475 | 464615..464830 | - | 216 | WP_202116934.1 | hypothetical protein | - |
| J1G50_RS02480 | 464793..465137 | - | 345 | WP_160421850.1 | DUF2570 family protein | - |
| J1G50_RS02485 | 465110..465655 | - | 546 | WP_160405306.1 | lysozyme | - |
| J1G50_RS02490 | 465630..465905 | - | 276 | WP_202116933.1 | hypothetical protein | - |
| J1G50_RS02495 | 466009..466473 | + | 465 | WP_005714705.1 | hypothetical protein | - |
| J1G50_RS02500 | 466466..466645 | - | 180 | WP_021109607.1 | hypothetical protein | - |
| J1G50_RS02505 | 466837..467013 | - | 177 | WP_005714781.1 | hypothetical protein | - |
| J1G50_RS02510 | 467310..467528 | + | 219 | WP_012621837.1 | hypothetical protein | - |
| J1G50_RS02515 | 467537..467914 | - | 378 | WP_160405308.1 | antitermination protein | - |
| J1G50_RS02520 | 467911..468315 | - | 405 | WP_160405310.1 | RusA family crossover junction endodeoxyribonuclease | - |
| J1G50_RS02525 | 468312..468602 | - | 291 | WP_021110734.1 | DUF1364 domain-containing protein | - |
| J1G50_RS02530 | 468708..468875 | + | 168 | WP_200859958.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J1G50_RS02535 | 468914..469321 | + | 408 | WP_021110735.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J1G50_RS02540 | 469355..469783 | - | 429 | WP_164689675.1 | recombination protein NinB | - |
| J1G50_RS02545 | 469819..470016 | - | 198 | WP_071610285.1 | hypothetical protein | - |
| J1G50_RS02550 | 470039..470710 | - | 672 | WP_160405312.1 | holin | - |
| J1G50_RS02555 | 470710..471495 | - | 786 | WP_075593099.1 | replication protein | - |
| J1G50_RS02560 | 471492..472145 | - | 654 | WP_021118456.1 | phage regulatory protein/antirepressor Ant | - |
| J1G50_RS02565 | 472236..472481 | - | 246 | WP_160405314.1 | hypothetical protein | - |
| J1G50_RS02570 | 472502..472708 | - | 207 | WP_012621794.1 | helix-turn-helix transcriptional regulator | - |
| J1G50_RS02575 | 472844..473497 | + | 654 | WP_005714960.1 | LexA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 436386..531621 | 95235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 56 a.a. Molecular weight: 6272.42 Da Isoelectric Point: 11.0319
>T196466 WP_200859958.1 NZ_CP071489:468708-468875 [Glaesserella parasuis]
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
MIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
Download Length: 168 bp
>T196466 NZ_CP095134:10019-10501 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14904.94 Da Isoelectric Point: 4.6143
>AT196466 WP_021110735.1 NZ_CP071489:468914-469321 [Glaesserella parasuis]
MLYPLIFEQVSDGYVVAIPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
MLYPLIFEQVSDGYVVAIPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
Download Length: 408 bp
>AT196466 NZ_CP095134:9765-10031 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|