Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 454476..455112 Replicon chromosome
Accession NZ_CP071489
Organism Glaesserella parasuis strain YHP1815

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYT4
Locus tag J1G50_RS02435 Protein ID WP_021113607.1
Coordinates 454476..454652 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143CEF9
Locus tag J1G50_RS02440 Protein ID WP_021113608.1
Coordinates 454699..455112 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G50_RS02410 451830..452210 - 381 WP_010786782.1 YacL family protein -
J1G50_RS02415 452294..452581 - 288 Protein_464 excinuclease ABC subunit UvrA -
J1G50_RS02420 452509..453033 - 525 WP_021112309.1 hypothetical protein -
J1G50_RS02425 453087..453599 - 513 WP_160421845.1 tail assembly protein -
J1G50_RS02430 453629..454390 - 762 WP_160405333.1 C40 family peptidase -
J1G50_RS02435 454476..454652 + 177 WP_021113607.1 type II toxin-antitoxin system HicA family toxin Toxin
J1G50_RS02440 454699..455112 + 414 WP_021113608.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1G50_RS02445 455109..455846 - 738 WP_160405297.1 phage minor tail protein L -
J1G50_RS02450 455856..459521 - 3666 WP_160405299.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 436386..531621 95235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6704.84 Da        Isoelectric Point: 10.8513

>T196465 WP_021113607.1 NZ_CP071489:454476-454652 [Glaesserella parasuis]
MKQSEFLRWLIAQGVVKEEGSKHIKLYYNGNQSTMPRQPSKEIKNGTMRAIKKQLGLN

Download         Length: 177 bp

>T196465 NZ_CP095134:c6132-5827 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGGCGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAGCTCTATCCGGTGG
TGTACATCGGGGACGAGAGCTGGCGCCTGATGACCACGGACATGGCCAGCGTCCCGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCCGCCACCGGGAAAATGACATCAAAAACGCAATAAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15572.78 Da        Isoelectric Point: 4.3878

>AT196465 WP_021113608.1 NZ_CP071489:454699-455112 [Glaesserella parasuis]
MLYPARFEFEDGSYNVSFRDIPEALTCGDNYEDALEMAKDALLTSMDFYFEDHRKVPLPSPPQEGEVLIELPTSIFAKVL
LLNEMVDQNISNVELAKRIAVKPQEVQRITNLGHSTKIDTIARAINALDKQFELRVV

Download         Length: 414 bp

>AT196465 NZ_CP095134:c6352-6134 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAAGCCCGACGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCTG
AGGTTGCCCGGTTTATTGAAAAGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYT4

Antitoxin

Source ID Structure
AlphaFold DB A0A143CEF9

References