Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1683066..1684753 Replicon chromosome
Accession NZ_CP071487
Organism Glaesserella parasuis strain YHP1818

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag J1G47_RS08600 Protein ID WP_160416009.1
Coordinates 1683410..1684753 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J1G47_RS08595 Protein ID WP_015940035.1
Coordinates 1683066..1683410 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G47_RS08575 1679134..1680084 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
J1G47_RS08580 1680112..1680957 - 846 WP_207326577.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
J1G47_RS08585 1680959..1681591 - 633 WP_005713149.1 lipoprotein insertase outer membrane protein LolB -
J1G47_RS08590 1681712..1683037 - 1326 WP_207326578.1 ATP-dependent RNA helicase SrmB -
J1G47_RS08595 1683066..1683410 - 345 WP_015940035.1 helix-turn-helix domain-containing protein Antitoxin
J1G47_RS08600 1683410..1684753 - 1344 WP_160416009.1 HipA domain-containing protein Toxin
J1G47_RS08605 1684867..1685304 - 438 WP_015940033.1 ribosomal protein S18-alanine N-acetyltransferase -
J1G47_RS08610 1685546..1685986 - 441 WP_015940032.1 M23 family metallopeptidase -
J1G47_RS08615 1685988..1686401 - 414 WP_005713136.1 DNA polymerase III subunit psi -
J1G47_RS08620 1686484..1687425 + 942 WP_207326579.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
J1G47_RS08625 1687575..1689752 + 2178 WP_160416360.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51129.28 Da        Isoelectric Point: 5.6578

>T196464 WP_160416009.1 NZ_CP071487:c1684753-1683410 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDNLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T196464 NZ_CP095133:57572-58054 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13225.52 Da        Isoelectric Point: 10.2782

>AT196464 WP_015940035.1 NZ_CP071487:c1683410-1683066 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Download         Length: 345 bp

>AT196464 NZ_CP095133:57318-57584 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References