Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1644345..1645122 Replicon chromosome
Accession NZ_CP071487
Organism Glaesserella parasuis strain YHP1818

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag J1G47_RS08380 Protein ID WP_005710654.1
Coordinates 1644345..1644845 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag J1G47_RS08385 Protein ID WP_005710653.1
Coordinates 1644835..1645122 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1G47_RS08345 1639471..1639626 - 156 WP_021116533.1 YoaH family protein -
J1G47_RS08350 1639644..1640372 - 729 WP_021112446.1 tRNA pseudouridine(65) synthase TruC -
J1G47_RS08355 1640369..1640683 - 315 WP_005710664.1 YqcC family protein -
J1G47_RS08360 1640725..1641639 - 915 WP_021113663.1 N-acetylmuramic acid 6-phosphate etherase -
J1G47_RS08365 1641651..1642766 - 1116 WP_043894690.1 anhydro-N-acetylmuramic acid kinase -
J1G47_RS08370 1642920..1643255 - 336 WP_016527793.1 outer membrane protein assembly factor BamE -
J1G47_RS08375 1643316..1644317 - 1002 WP_021116692.1 nucleoid-associated protein YejK -
J1G47_RS08380 1644345..1644845 - 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
J1G47_RS08385 1644835..1645122 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
J1G47_RS08390 1645268..1645657 + 390 WP_207326570.1 Rid family detoxifying hydrolase -
J1G47_RS08395 1645661..1646398 + 738 WP_207326571.1 peptidoglycan editing factor PgeF -
J1G47_RS08400 1646573..1648150 + 1578 WP_207326572.1 FAD-binding protein -
J1G47_RS08405 1648254..1648754 + 501 WP_021115009.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T196463 WP_005710654.1 NZ_CP071487:c1644845-1644345 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T196463 NZ_CP095132:c5371255-5370872 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT196463 WP_005710653.1 NZ_CP071487:c1645122-1644835 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT196463 NZ_CP095132:c5371497-5371255 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References