Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4889400..4889965 Replicon chromosome
Accession NZ_CP071465
Organism Streptomyces nodosus strain ZJB2016050

Toxin (Protein)


Gene name doc Uniprot ID A0A0B5DKC0
Locus tag J0917_RS21290 Protein ID WP_043440629.1
Coordinates 4889597..4889965 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0B5DLL9
Locus tag J0917_RS21285 Protein ID WP_043440632.1
Coordinates 4889400..4889597 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0917_RS21270 4886525..4887598 + 1074 WP_052454104.1 SUKH-4 family immunity protein -
J0917_RS21280 4887910..4889367 + 1458 WP_043440634.1 MFS transporter -
J0917_RS21285 4889400..4889597 + 198 WP_043440632.1 hypothetical protein Antitoxin
J0917_RS21290 4889597..4889965 + 369 WP_043440629.1 Fic family protein Toxin
J0917_RS21295 4890102..4891895 + 1794 WP_043440627.1 DEAD/DEAH box helicase -
J0917_RS21300 4892262..4892903 + 642 WP_043440625.1 helix-turn-helix domain-containing protein -
J0917_RS21305 4892995..4893786 + 792 WP_043440622.1 hypothetical protein -
J0917_RS21310 4893854..4894036 - 183 WP_043440619.1 hypothetical protein -
J0917_RS21315 4894049..4894630 - 582 WP_043448549.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13664.57 Da        Isoelectric Point: 5.1244

>T196460 WP_043440629.1 NZ_CP071465:4889597-4889965 [Streptomyces nodosus]
MYHLTLPELLNLAQRLGADEVRDFGLLDSALARPRSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRIAWYATWVFL
HMNGHPLDSGFDVDEAERFVLDVCQGALDVPKIAARLPEFAR

Download         Length: 369 bp

>T196460 NZ_CP095132:c4772538-4772005 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7174.02 Da        Isoelectric Point: 5.0372

>AT196460 WP_043440632.1 NZ_CP071465:4889400-4889597 [Streptomyces nodosus]
MAGLNVRFTDEELDALRERAAAEGRSMQAFAHEAVIAAINEHARLFNEAAEHVLQASAELNRRLA

Download         Length: 198 bp

>AT196460 NZ_CP095132:c4772815-4772549 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5DKC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0B5DLL9

References