Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 9238..9760 Replicon plasmid p1
Accession NZ_CP071437
Organism Escherichia coli strain EcPNK006

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag J1137_RS22040 Protein ID WP_000220560.1
Coordinates 9238..9519 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag J1137_RS22045 Protein ID WP_000121743.1
Coordinates 9509..9760 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1137_RS22010 4238..4645 - 408 WP_001214976.1 cysteine hydrolase -
J1137_RS22015 4634..6385 + 1752 Protein_6 Tn3-like element TnAs1 family transposase -
J1137_RS22020 6774..7471 - 698 Protein_7 IS1 family transposase -
J1137_RS22025 7527..7778 + 252 Protein_8 IS200/IS605 family transposase -
J1137_RS22030 7970..8164 - 195 WP_053273080.1 hypothetical protein -
J1137_RS22035 8466..9163 - 698 Protein_10 IS1 family transposase -
J1137_RS22040 9238..9519 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1137_RS22045 9509..9760 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
J1137_RS22050 10995..11831 + 837 WP_001050931.1 replication initiation protein -
J1137_RS22055 11871..12317 + 447 Protein_14 hypothetical protein -
J1137_RS22060 12385..12810 + 426 WP_000202942.1 hypothetical protein -
J1137_RS22065 12807..13784 - 978 WP_024245156.1 hypothetical protein -
J1137_RS22070 13809..14090 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / sul3 / aadA2 / dfrA12 - 1..37036 37036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T196356 WP_000220560.1 NZ_CP071437:c9519-9238 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T196356 NZ_CP095092:1784-2071 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT196356 WP_000121743.1 NZ_CP071437:c9760-9509 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT196356 NZ_CP095092:2058-2372 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References