Detailed information of TA system TA196319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2093610..2094240
• Replicon: chromosome
• Accession: NZ_CP071405
• Organism: Pantoea deleyi strain LMG24200

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J1C59_RS09825
• Protein ID: WP_128085847.1
• Coordinates: 2094058..2094240 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J1C59_RS09820
• Protein ID: WP_128085848.1
• Coordinates: 2093610..2094035 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1C59_RS09810	2089201..2090355	+	1155	WP_140917219.1	efflux RND transporter periplasmic adaptor subunit	-
J1C59_RS09815	2090368..2093520	+	3153	WP_128085849.1	multidrug efflux RND transporter permease subunit OqxB	-
J1C59_RS09820	2093610..2094035	-	426	WP_128085848.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J1C59_RS09825	2094058..2094240	-	183	WP_128085847.1	type II toxin-antitoxin system HicA family toxin	Toxin
J1C59_RS09830	2094405..2094899	-	495	WP_128085846.1	Rrf2 family transcriptional regulator	-
J1C59_RS09835	2095106..2096290	-	1185	WP_140917218.1	MFS transporter	-
J1C59_RS09840	2096489..2097418	+	930	WP_140917217.1	DNA replication terminus site-binding protein	-
J1C59_RS09845	2097454..2098851	-	1398	WP_128085845.1	class II fumarate hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6983.10 Da
• Isoelectric Point: 11.1468

>T196319 WP_128085847.1 NZ_CP071405:c2094240-2094058 [Pantoea deleyi]
MKYSEFRRWLIQQGAILVKHRRGSSHFKVFSGDRQSVFPDHGAKEMPEGTRKKILKDPGL

Nucleotide

• Length: 183 bp

>T196319 NZ_CP095086:4304067-4304405 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15422.79 Da
• Isoelectric Point: 4.7911

>AT196319 WP_128085848.1 NZ_CP071405:c2094035-2093610 [Pantoea deleyi]
MFNYAVRLTHDLKTDSWEVSCRDLPLLHSVGDTVEEALAEAADGLVAAIFLEMDARRPIPLASDAQQGEYIVSVPVLVAM
KAALYNAMIETGTRKADLARQLGVNGPQVDRLLDVEHSSKVEKVELALAQLGRKARVEILI

Nucleotide

• Length: 426 bp

>AT196319 NZ_CP095086:c4304072-4303996 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT