Detailed information of TA system TA196318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2016481..2018042
• Replicon: chromosome
• Accession: NZ_CP071405
• Organism: Pantoea deleyi strain LMG24200

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: J1C59_RS09475
• Protein ID: WP_128085474.1
• Coordinates: 2016729..2018042 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J1C59_RS09470
• Protein ID: WP_128085475.1
• Coordinates: 2016481..2016729 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1C59_RS09450	2011735..2013960	+	2226	WP_140917236.1	iron ABC transporter permease	-
J1C59_RS09455	2013957..2015018	+	1062	WP_128085478.1	ABC transporter ATP-binding protein	-
J1C59_RS09460	2015042..2015833	+	792	WP_128085477.1	inositol monophosphatase family protein	-
J1C59_RS09465	2015835..2016296	-	462	WP_128085476.1	GNAT family N-acetyltransferase	-
J1C59_RS09470	2016481..2016729	+	249	WP_128085475.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
J1C59_RS09475	2016729..2018042	+	1314	WP_128085474.1	type II toxin-antitoxin system HipA family toxin	Toxin
J1C59_RS09480	2018151..2018357	+	207	WP_128085473.1	type II toxin-antitoxin system MqsA family antitoxin	-
J1C59_RS09485	2018713..2020758	+	2046	WP_128085472.1	FUSC family protein	-
J1C59_RS09490	2021028..2021363	-	336	WP_128085471.1	gamma-glutamylcyclotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-66)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49050.54 Da
• Isoelectric Point: 8.8584

>T196318 WP_128085474.1 NZ_CP071405:2016729-2018042 [Pantoea deleyi]
MQRLIAWMNGERVGVLTRQRNGAHAFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IRSRQPFDLLQEIGRDSVGATMLLPPDMPLPALNARYEVLDESRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDAGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARELGIEVPQATIIRAGTMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMQFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDLISAYPVLGGTGLNKRALKLAMGLRASRGKKTEIDKIFPRHFIATARSVSFDTDSLQQIFDFFVRAFP
QAVVAVRDMLPSGFPQHIADAIFSHSLIMLERLRHQT

Nucleotide

• Length: 1314 bp

>T196318 NZ_CP095086:4226087-4226239 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9236.55 Da
• Isoelectric Point: 5.0190

>AT196318 WP_128085475.1 NZ_CP071405:2016481-2016729 [Pantoea deleyi]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDNTSLATLFKLLQSLELSLDVLEKEAATTPPIDDED
AW

Nucleotide

• Length: 249 bp

>AT196318 NZ_CP095086:c4226038-4225981 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA