Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 623421..624013 Replicon chromosome
Accession NZ_CP071405
Organism Pantoea deleyi strain LMG24200

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J1C59_RS03040 Protein ID WP_128085149.1
Coordinates 623421..623675 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J1C59_RS03045 Protein ID WP_128085148.1
Coordinates 623672..624013 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1C59_RS03015 618830..619834 + 1005 WP_128085153.1 phosphoadenosine phosphosulfate reductase family protein -
J1C59_RS03020 619831..622080 + 2250 WP_208721882.1 replication endonuclease -
J1C59_RS03025 622281..622472 + 192 WP_128085152.1 hypothetical protein -
J1C59_RS03030 622491..622724 + 234 Protein_585 DinI-like family protein -
J1C59_RS03035 622799..623044 + 246 WP_128085151.1 hypothetical protein -
J1C59_RS03040 623421..623675 + 255 WP_128085149.1 type II toxin-antitoxin system HicA family toxin Toxin
J1C59_RS03045 623672..624013 + 342 WP_128085148.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1C59_RS03050 624071..625690 - 1620 WP_128085147.1 hypothetical protein -
J1C59_RS03055 625814..626854 - 1041 WP_128085146.1 phage portal protein -
J1C59_RS03060 626854..628617 - 1764 WP_128085145.1 terminase ATPase subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 614341..681733 67392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9496.02 Da        Isoelectric Point: 11.3526

>T196317 WP_128085149.1 NZ_CP071405:623421-623675 [Pantoea deleyi]
MNKRHQKTLSDVFARPVSGSIKWSDIESLFIALGAEVHEREGSRIAVLLKGQKKIFHRPHPRPTTDKGAVNSIRLWLDSL
GIRP

Download         Length: 255 bp

>T196317 NZ_CP095086:c4189141-4188827 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12555.19 Da        Isoelectric Point: 4.6212

>AT196317 WP_128085148.1 NZ_CP071405:623672-624013 [Pantoea deleyi]
MNNTLKIDGHLAVITFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGSISLAVFLEECRKDDIEPYKTFSGKVTTRLTP
ERHQALAVTAQAHGVSINELLNEGVDLVIEKHS

Download         Length: 342 bp

>AT196317 NZ_CP095086:c4189377-4189144 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References