Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 726515..727182 Replicon plasmid p1
Accession NZ_CP071400
Organism Rhizobium leguminosarum strain OyaliB

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J0664_RS27190 Protein ID WP_168342716.1
Coordinates 726772..727182 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J0664_RS27185 Protein ID WP_168342717.1
Coordinates 726515..726772 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0664_RS27160 721555..722757 - 1203 WP_207158906.1 acetyl-CoA C-acyltransferase -
J0664_RS27165 722735..724264 - 1530 WP_207158907.1 AMP-binding protein -
J0664_RS27170 724294..724710 - 417 WP_207158908.1 YbgC/FadM family acyl-CoA thioesterase -
J0664_RS27175 724764..725738 + 975 WP_168342718.1 zinc-dependent alcohol dehydrogenase family protein -
J0664_RS27180 725846..726406 + 561 WP_168342857.1 DUF3299 domain-containing protein -
J0664_RS27185 726515..726772 + 258 WP_168342717.1 antitoxin Antitoxin
J0664_RS27190 726772..727182 + 411 WP_168342716.1 type II toxin-antitoxin system VapC family toxin Toxin
J0664_RS27195 727248..729434 - 2187 WP_168342715.1 catalase/peroxidase HPI -
J0664_RS27200 729578..730492 + 915 WP_168342714.1 hydrogen peroxide-inducible genes activator -
J0664_RS27205 730514..731335 - 822 WP_077980583.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..1230906 1230906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14781.89 Da        Isoelectric Point: 4.8998

>T196312 WP_168342716.1 NZ_CP071400:726772-727182 [Rhizobium leguminosarum]
VITHLIDTNAVIALIGRKSETLLKRVIDSDEGSIGLSTVVMHELYYGAYKSAKTSYNLETLRLFVADFSVVGFEQDDALA
AGEIRAALAAKGTPIGPYDVLIAAQARTRDLVLVTNNVGEFRRVDGLIVEDWTVGR

Download         Length: 411 bp

>T196312 NZ_CP095086:2796904-2797011 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9806.91 Da        Isoelectric Point: 4.6558

>AT196312 WP_168342717.1 NZ_CP071400:726515-726772 [Rhizobium leguminosarum]
MPQYARVFQSGNSQAVRLPKEFRFDVDQVEVTREGDAVILRPRADRGMRWASLHSALERGLSDDFMAEGREQPEGQERPD
LQDLF

Download         Length: 258 bp

>AT196312 NZ_CP095086:c2796851-2796790 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGGTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References