Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3217781..3219270 Replicon chromosome
Accession NZ_CP071399
Organism Rhizobium leguminosarum strain OyaliB

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag J0664_RS16090 Protein ID WP_207156202.1
Coordinates 3218008..3219270 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag J0664_RS16085 Protein ID WP_162118261.1
Coordinates 3217781..3218011 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0664_RS16070 3215632..3215913 - 282 WP_003546080.1 hypothetical protein -
J0664_RS16075 3215963..3216649 - 687 WP_207156200.1 PspA/IM30 family protein -
J0664_RS16080 3216760..3217368 + 609 WP_207156201.1 WHG domain-containing protein -
J0664_RS16085 3217781..3218011 + 231 WP_162118261.1 helix-turn-helix transcriptional regulator Antitoxin
J0664_RS16090 3218008..3219270 + 1263 WP_207156202.1 HipA domain-containing protein Toxin
J0664_RS16095 3219731..3220510 + 780 WP_207156203.1 SDR family NAD(P)-dependent oxidoreductase -
J0664_RS16100 3220655..3222006 + 1352 Protein_3182 restriction endonuclease subunit R -
J0664_RS16105 3222010..3222789 + 780 WP_207156204.1 DUF429 domain-containing protein -
J0664_RS16115 3223190..3224107 + 918 WP_207156205.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45312.06 Da        Isoelectric Point: 5.7544

>T196309 WP_207156202.1 NZ_CP071399:3218008-3219270 [Rhizobium leguminosarum]
MTSRLLNVWWDGRIVGQFTQDRHGDIGFVYARAWLDDDKTLPLSVSLPKRPEQFTRRECRPFFGGLLPEESQRLAAARAL
GVSPANDFALLDHLGGDVAGALQLLAEGEAPAGTGSIADRQPVPLDEAGIVAVLEALPVRPLLAGEEGLRLSLAGAQSKL
PVVLVDGRIGLPLPGQATTHILKPPIARFKATTENEAFVMRLAAAIGLDVAAVEPRYVQGRPFLLVERYDRARGAGGLVH
RIHQEDFCQALGVPPETKYASEGGPTFKDCFDLIRRISARPAGDVLKLLDAAIFNLIAGNADAHGKNFSILYDSQGPRLA
KLYDLLSTVIYPELSPRLAMRIGKCATLAEMDAEGWKAFAAEAGVGTPLLRRRVNELCDKVLTLTGKVADELADVSPDRD
PIDQIAGVITDRAETARLTL

Download         Length: 1263 bp

>T196309 NZ_CP095086:2252573-2252675 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8187.52 Da        Isoelectric Point: 10.3068

>AT196309 WP_162118261.1 NZ_CP071399:3217781-3218011 [Rhizobium leguminosarum]
MPKHVQSPADIGALVRSTRKEQNLRQDELAGVAGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSLDILAPGERRR

Download         Length: 231 bp

>AT196309 NZ_CP095086:c2252713-2252445 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References