Detailed information of TA system TA196300

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4735566..4736385
• Replicon: chromosome
• Accession: NZ_CP071393
• Organism: Klebsiella michiganensis strain Kmfe267

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: J1F62_RS22310
• Protein ID: WP_004110819.1
• Coordinates: 4736128..4736385 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: J1F62_RS22305
• Protein ID: WP_187228637.1
• Coordinates: 4735566..4736117 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1F62_RS22290	4730936..4732333	+	1398	WP_014228060.1	MFS transporter	-
J1F62_RS22295	4732455..4733795	+	1341	WP_014228059.1	carbohydrate porin	-
J1F62_RS22300	4733920..4735548	-	1629	WP_109241012.1	SAM-dependent methyltransferase	-
J1F62_RS22305	4735566..4736117	-	552	WP_187228637.1	N-acetyltransferase	Antitoxin
J1F62_RS22310	4736128..4736385	-	258	WP_004110819.1	YjhX family toxin	Toxin
J1F62_RS22315	4737061..4738245	+	1185	WP_014228054.1	mannonate dehydratase	-
J1F62_RS22320	4738319..4739794	+	1476	WP_080528514.1	fructuronate reductase	-
J1F62_RS22325	4739933..4740709	+	777	WP_025107251.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T196300 WP_004110819.1 NZ_CP071393:c4736385-4736128 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T196300 NZ_CP095083:c4783386-4783213 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19954.87 Da
• Isoelectric Point: 6.5770

>AT196300 WP_187228637.1 NZ_CP071393:c4736117-4735566 [Klebsiella michiganensis]
MTNHSFTFHIASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRLGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT196300 NZ_CP095083:c4783710-4783414 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2