Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 661000..661592 Replicon chromosome
Accession NZ_CP071393
Organism Klebsiella michiganensis strain Kmfe267

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag J1F62_RS03200 Protein ID WP_004105955.1
Coordinates 661218..661592 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag J1F62_RS03195 Protein ID WP_004105957.1
Coordinates 661000..661221 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1F62_RS03175 656557..657111 + 555 WP_014226934.1 YgjV family protein -
J1F62_RS03180 657130..658377 - 1248 WP_004105963.1 serine/threonine transporter SstT -
J1F62_RS03185 658632..659600 - 969 WP_048260487.1 TerC family protein -
J1F62_RS03190 659851..660840 - 990 WP_049083892.1 Gfo/Idh/MocA family oxidoreductase -
J1F62_RS03195 661000..661221 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J1F62_RS03200 661218..661592 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
J1F62_RS03205 661572..662075 - 504 WP_004105953.1 M48 family metallopeptidase -
J1F62_RS03210 662154..663797 - 1644 WP_064404300.1 glycoside hydrolase family 43 protein -
J1F62_RS03215 663926..664792 - 867 WP_201993138.1 AraC family transcriptional regulator -
J1F62_RS03220 664900..666243 + 1344 WP_200913967.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T196287 WP_004105955.1 NZ_CP071393:661218-661592 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T196287 NZ_CP095083:965401-965808 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT196287 WP_004105957.1 NZ_CP071393:661000-661221 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT196287 NZ_CP095083:965154-965420 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References