Detailed information of TA system TA196281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4885066..4886747
• Replicon: chromosome
• Accession: NZ_CP071385
• Organism: Klebsiella pneumoniae strain wxc2020

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: J1F26_RS23935
• Protein ID: WP_002885155.1
• Coordinates: 4885066..4885983 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: J1F26_RS23940
• Protein ID: WP_207604349.1
• Coordinates: 4885989..4886747 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J1F26_RS23915	4880372..4881892	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
J1F26_RS23920	4881889..4882887	+	999	WP_002885172.1	ribose ABC transporter permease	-
J1F26_RS23925	4882918..4883859	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
J1F26_RS23930	4883934..4884941	+	1008	WP_207604348.1	carbohydrate kinase family protein	-
J1F26_RS23935	4885066..4885983	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J1F26_RS23940	4885989..4886747	-	759	WP_207604349.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
J1F26_RS23945	4886833..4887561	-	729	WP_002885152.1	response regulator transcription factor	-
J1F26_RS23950	4887834..4889981	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
J1F26_RS23955	4890211..4890897	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T196281 WP_002885155.1 NZ_CP071385:c4885983-4885066 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T196281 NZ_CP095081:c1269534-1268758 [Streptococcus dysgalactiae]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGAATTAGCCTTAAAACGGACCATTCGCCCCTTAACTCGTGGTAAAAT
GACATCAGTTAACCCCAAAGCCATCTTAATTGGTGGGCAAAGCGGAGCGGGTAAGACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATCATTATTATTGACGGTGATAGCTACCGTTCTTTACACCCGAATTATCTAGCTTTACAAGAA
GAGTACACGAAGGATAGCGTGGATTATACCAAAGGCTTTGCAGGAAAAATGGTGGAACATCTTGTGGATGAGTTAAGTAA
ACAAGGTTATCATTTGTTAATTGAAGGAACCTTAAGAACGACATCAGTCCCAAGAAAAACTGCGCAGATATTAAAATCAA
GGGGCTATCAAGTCTCTTTAGCTTTGATAGCGACCAAGCCTGAATTGTCATATCTCAGTACCTTAATCCGCTATGAGGAA
GTCTATGCGGTGAACCCAAGCCAGGCTAGAGCAACTCCTAAAGAGCATCACGATGGTATTGTAGAGCATTTATTTGATAA
CTTACGAGAGTTAGAAACTGATAAACTCTTTGACCAGATTCAAATTTATCAAAGAGACAGACGTTGTGTCTATTATTCTG
AAACAGATAAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGTAAGGTAGAGGAGGAGATGATG
AAGGTGGGACAGGAACAGTTGAGGGAAGTAGGTAGAAGGAATGAAAAAGATGCATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28610.01 Da
• Isoelectric Point: 10.1536

>AT196281 WP_207604349.1 NZ_CP071385:c4886747-4885989 [Klebsiella pneumoniae]
MAKKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT196281 NZ_CP095081:c1270010-1269534 [Streptococcus dysgalactiae]
ATGATTGGAGATAATATCAAATCCTTACGTAAAACCCATGATTTAACACAACCAGAGTTCGCAAATATTGTGGGAATTTC
ACGAAATAGCCTTAGTCGTTATGAAAATGGGACAAGCTCTGTTTCGACAGAACTTATTGATCGGATTTGTCAGAAATTCA
ATGTGTCTTATGTCGATATTTTGGGAGAAGAAAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGTGCAGCTATTTTATCCCAACTGTATCGCTATCAAGATAGTCAAGGAATCGCTTTTGATGATGA
GACCAGTCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTATCTTGTTCAATCGTTTGATG
AAGTGGAGCGCTACAATGGTTATTTGGATGGTATTGAGCGAATGTTGGAGCATGCTCATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11