Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4666311..4666827 Replicon chromosome
Accession NZ_CP071385
Organism Klebsiella pneumoniae strain wxc2020

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag J1F26_RS22805 Protein ID WP_004192395.1
Coordinates 4666311..4666595 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag J1F26_RS22810 Protein ID WP_004192397.1
Coordinates 4666585..4666827 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1F26_RS22780 4661728..4662036 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
J1F26_RS22785 4662121..4662294 + 174 WP_002886906.1 hypothetical protein -
J1F26_RS22790 4662297..4663040 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J1F26_RS22795 4663397..4665535 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J1F26_RS22800 4665843..4666307 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J1F26_RS22805 4666311..4666595 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J1F26_RS22810 4666585..4666827 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J1F26_RS22815 4666905..4668815 - 1911 WP_004152270.1 BglG family transcription antiterminator -
J1F26_RS22820 4668838..4669992 - 1155 WP_004178372.1 lactonase family protein -
J1F26_RS22825 4670059..4670799 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T196280 WP_004192395.1 NZ_CP071385:c4666595-4666311 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T196280 NZ_CP071385:c4666595-4666311 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT196280 WP_004192397.1 NZ_CP071385:c4666827-4666585 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT196280 NZ_CP071385:c4666827-4666585 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References