Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3960563..3961182 | Replicon | chromosome |
Accession | NZ_CP071385 | ||
Organism | Klebsiella pneumoniae strain wxc2020 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | J1F26_RS19410 | Protein ID | WP_002892050.1 |
Coordinates | 3960964..3961182 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | J1F26_RS19405 | Protein ID | WP_002892066.1 |
Coordinates | 3960563..3960937 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J1F26_RS19395 | 3955715..3956908 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
J1F26_RS19400 | 3956931..3960077 | + | 3147 | WP_207604332.1 | multidrug efflux RND transporter permease subunit AcrB | - |
J1F26_RS19405 | 3960563..3960937 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
J1F26_RS19410 | 3960964..3961182 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
J1F26_RS19415 | 3961341..3961907 | + | 567 | WP_004191639.1 | maltose O-acetyltransferase | - |
J1F26_RS19420 | 3961879..3962019 | - | 141 | WP_004147370.1 | hypothetical protein | - |
J1F26_RS19425 | 3962040..3962510 | + | 471 | WP_002892026.1 | YlaC family protein | - |
J1F26_RS19430 | 3962485..3963936 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
J1F26_RS19435 | 3964037..3964735 | + | 699 | WP_002892021.1 | GNAT family N-acetyltransferase | - |
J1F26_RS19440 | 3964732..3964872 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
J1F26_RS19445 | 3964872..3965135 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T196278 WP_002892050.1 NZ_CP071385:3960964-3961182 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T196278 NZ_CP095073:c4174495-4174145 [Halobacillus sp. SSBR10-3]
TTGATAGTCAAACGAGGAGACGTTTATTTCGCTGATTTGTCCCCGGTGGTGGGTTCTGAACAAGGCGGGGTTCGTCCAGT
ACTCATTCTTCAAAACGACATCGGCAATCGTTTTAGTCCTACCGTAATCGTTGCCGCGATTACAGCGCAAATACAAAAAG
CCAAACTACCTACACACGTTGAAATTGATGCAGCCAAATATGGTTTTGAACGAAATTCAGTAATCCTGCTGGAGCAAATC
AGAACGATTGATAAACAACGTTTGACCGACAAGATTACTCAACTTGATGATCCTATGATGCAGCGCGTAAATGAAGCGCT
GCAAATTAGTCTTGGATTAATTGATTTTTAA
TTGATAGTCAAACGAGGAGACGTTTATTTCGCTGATTTGTCCCCGGTGGTGGGTTCTGAACAAGGCGGGGTTCGTCCAGT
ACTCATTCTTCAAAACGACATCGGCAATCGTTTTAGTCCTACCGTAATCGTTGCCGCGATTACAGCGCAAATACAAAAAG
CCAAACTACCTACACACGTTGAAATTGATGCAGCCAAATATGGTTTTGAACGAAATTCAGTAATCCTGCTGGAGCAAATC
AGAACGATTGATAAACAACGTTTGACCGACAAGATTACTCAACTTGATGATCCTATGATGCAGCGCGTAAATGAAGCGCT
GCAAATTAGTCTTGGATTAATTGATTTTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT196278 WP_002892066.1 NZ_CP071385:3960563-3960937 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT196278 NZ_CP095073:c4174782-4174501 [Halobacillus sp. SSBR10-3]
ATGGTTTTGTCCGACAGCATGCAGGAGATTGTCATTCGGATTCCGGATAACCTACTCAATGAAGTGGATGGCTTTATTCA
ACTCGAAAACAGTGATCGGAGCGATTTCATGTGTCAAGCAACAAAAATGTATTTGCGTGAGAAAAAGCAGCGCCATATTA
GAGAGACAATGCGCAGAGGCTACATGGAGATGGCAAAAATTAACTTAAACATCGCTTCAGAAGCGTTTCAGGCTGAAGAG
GAGGCAGAACACACCCTGGAGCAATTAGTGGGCGGGGTGTGA
ATGGTTTTGTCCGACAGCATGCAGGAGATTGTCATTCGGATTCCGGATAACCTACTCAATGAAGTGGATGGCTTTATTCA
ACTCGAAAACAGTGATCGGAGCGATTTCATGTGTCAAGCAACAAAAATGTATTTGCGTGAGAAAAAGCAGCGCCATATTA
GAGAGACAATGCGCAGAGGCTACATGGAGATGGCAAAAATTAACTTAAACATCGCTTCAGAAGCGTTTCAGGCTGAAGAG
GAGGCAGAACACACCCTGGAGCAATTAGTGGGCGGGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |