Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842753..843410 Replicon chromosome
Accession NZ_CP071385
Organism Klebsiella pneumoniae strain wxc2020

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J1F26_RS04230 Protein ID WP_002916310.1
Coordinates 843000..843410 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J1F26_RS04225 Protein ID WP_002916312.1
Coordinates 842753..843019 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1F26_RS04200 837909..839342 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J1F26_RS04205 839461..840189 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J1F26_RS04210 840239..840550 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
J1F26_RS04215 840714..841373 + 660 WP_002916317.1 hemolysin III family protein -
J1F26_RS04220 841524..842507 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J1F26_RS04225 842753..843019 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J1F26_RS04230 843000..843410 + 411 WP_002916310.1 protein YgfX Toxin
J1F26_RS04235 843417..843938 - 522 WP_002916308.1 flavodoxin FldB -
J1F26_RS04240 844039..844935 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J1F26_RS04245 844958..845671 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J1F26_RS04250 845677..847410 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T196268 WP_002916310.1 NZ_CP071385:843000-843410 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T196268 NZ_CP095045:1717650-1718000 [Leucobacter allii]
ATGTGGAGCGTGGACATCGAGCCGATCGCGAGATGGCTCGCTTCGCTGGACGATGACTCACGCGCCCAGGTGGTCGCCGC
GATCGAGCTGCTGGAAGACCGCGGTCCTCAACTCGGCCGGCCGATCGTCGACACGGTGTCCTCGTCGAAGCACCGAAACA
TGAAGGAGCTCAGACCTGGTTCCTCGGGGCGTTCCGAGCTGCGAGTACTGTTCGCCTTCGACCCGGAACGCTCAGCGATC
ATGCTGATCGCCGGCGACAAGACCGGCACCTGGAAACGCTGGTACAAGAAAAGCATCCCACTGGCCGACGACCTGTTCGA
CGACCACCTACGCAGCCTGAGAGGAAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT196268 WP_002916312.1 NZ_CP071385:842753-843019 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196268 NZ_CP095045:1718012-1718311 [Leucobacter allii]
ATGTCACTGAAAGACTTCATCGCCGAGCACCCCGTGGACCGGGAACTCGTCGACGCCCACAAGGAGCGGATGCTCGCCGA
GGTGCGCGCGTACCGGCTCCGCGAGCTGAGGGAAGCCGCTGGCCTGACGCAGGCCCAGCTCGCCGAGCGCATCGGCGTCG
GGCAGCGCCAGGTCTCCAAGATCGAGCACGGCGACCTGGACAGTGCGAAGGTCAGCACGGTCCGCGGTTACCTCGAAGCG
GTCGGCGGTTCCCTGGCGATCGAGTACGTTCTCGGCGACCAGCGCGTCCAGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References