Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3510797..3511460 Replicon chromosome
Accession NZ_CP071383
Organism Leclercia sp. 4-9-1-25

Toxin (Protein)


Gene name cptA Uniprot ID A0A0M3EX34
Locus tag JZ655_RS16990 Protein ID WP_046887112.1
Coordinates 3510797..3511213 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0M3EXE7
Locus tag JZ655_RS16995 Protein ID WP_040074142.1
Coordinates 3511194..3511460 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ655_RS16970 3506794..3508527 - 1734 WP_207292356.1 single-stranded-DNA-specific exonuclease RecJ -
JZ655_RS16975 3508533..3509246 - 714 WP_040074147.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JZ655_RS16980 3509272..3510168 - 897 WP_207292357.1 site-specific tyrosine recombinase XerD -
JZ655_RS16985 3510271..3510792 + 522 WP_207292358.1 flavodoxin FldB -
JZ655_RS16990 3510797..3511213 - 417 WP_046887112.1 protein YgfX Toxin
JZ655_RS16995 3511194..3511460 - 267 WP_040074142.1 FAD assembly factor SdhE Antitoxin
JZ655_RS17000 3511752..3512732 + 981 WP_207292359.1 tRNA-modifying protein YgfZ -
JZ655_RS17005 3512817..3513476 - 660 WP_040074140.1 hemolysin III family protein -
JZ655_RS17010 3513641..3513952 - 312 WP_040074139.1 N(4)-acetylcytidine aminohydrolase -
JZ655_RS17015 3514005..3514736 + 732 WP_046887115.1 MurR/RpiR family transcriptional regulator -
JZ655_RS17020 3514852..3516285 + 1434 WP_207292360.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16340.10 Da        Isoelectric Point: 10.7427

>T196263 WP_046887112.1 NZ_CP071383:c3511213-3510797 [Leclercia sp. 4-9-1-25]
VVLWQSDLRVSWRSQWMSLLLHGLVAAAILLMPWPLSYTPLWLLLLSLVVFDSVRSQRRINARQGEIKLFMDSRLRWQGK
EWEIVGSPWMINAGMMLRLRASEEQRCHHLWVSADSMDEGEWRDLRRMIAQQQPTQGR

Download         Length: 417 bp

>T196263 NZ_CP095023:3548911-3549255 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGACATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10516.99 Da        Isoelectric Point: 4.6761

>AT196263 WP_040074142.1 NZ_CP071383:c3511460-3511194 [Leclercia sp. 4-9-1-25]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEDKQLFIRLLECDDPDLFNWLMNHGEPADSELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196263 NZ_CP095023:3549252-3549581 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3EX34

Antitoxin

Source ID Structure
AlphaFold DB A0A0M3EXE7

References