Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2226024..2226790 Replicon chromosome
Accession NZ_CP071383
Organism Leclercia sp. 4-9-1-25

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JZ655_RS10710 Protein ID WP_207291744.1
Coordinates 2226299..2226790 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JZ655_RS10705 Protein ID WP_207291743.1
Coordinates 2226024..2226311 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ655_RS10685 2222067..2222954 - 888 WP_207291739.1 LysR family transcriptional regulator -
JZ655_RS10690 2223075..2224172 + 1098 WP_207291740.1 NADH:flavin oxidoreductase -
JZ655_RS10695 2224206..2224544 - 339 WP_207291741.1 hypothetical protein -
JZ655_RS10700 2224708..2225856 + 1149 WP_207291742.1 PD-(D/E)XK nuclease family protein -
JZ655_RS10705 2226024..2226311 + 288 WP_207291743.1 DUF1778 domain-containing protein Antitoxin
JZ655_RS10710 2226299..2226790 + 492 WP_207291744.1 GNAT family N-acetyltransferase Toxin
JZ655_RS10715 2226857..2227612 - 756 WP_207291745.1 DeoR family transcriptional regulator -
JZ655_RS10720 2227700..2228284 + 585 WP_040075708.1 GDP-mannose pyrophosphatase -
JZ655_RS10725 2228292..2228654 + 363 WP_207291746.1 DUF4406 domain-containing protein -
JZ655_RS10730 2228728..2229486 + 759 WP_207291747.1 trans-aconitate 2-methyltransferase -
JZ655_RS10735 2229493..2230614 - 1122 WP_207291748.1 porin OmpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(6-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17699.52 Da        Isoelectric Point: 9.8614

>T196254 WP_207291744.1 NZ_CP071383:2226299-2226790 [Leclercia sp. 4-9-1-25]
VGKVTAPVPLNSSHILAEFHCGEAALDEWIKHRGLKNQSMGAARTFVVCRGNASQVIGFYSLATGSVTHAVAPGSLRRNM
PDPVPVIILARLAVDASFHSKGLGADLLHDAVLRCCRVAENIGVRAIMVHAISDRARQFYIHHGFTPSQTQERTLFLRLP
IIT

Download         Length: 492 bp

>T196254 NZ_CP095023:2928870-2929310 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10855.56 Da        Isoelectric Point: 5.1530

>AT196254 WP_207291743.1 NZ_CP071383:2226024-2226311 [Leclercia sp. 4-9-1-25]
MLYKGGSMKSDVQLNIRAKEAQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIEMLDAPVTAN
PAMDKLLARKPQWEK

Download         Length: 288 bp

>AT196254 NZ_CP095023:2928596-2928883 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References