Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2217878..2219481 Replicon chromosome
Accession NZ_CP071383
Organism Leclercia sp. 4-9-1-25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JZ655_RS10670 Protein ID WP_207291736.1
Coordinates 2217878..2219212 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JZ655_RS10675 Protein ID WP_207291737.1
Coordinates 2219212..2219481 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ655_RS10645 2214189..2214515 - 327 WP_040075693.1 YebG family protein -
JZ655_RS10650 2214619..2214978 - 360 WP_207291733.1 DUF4440 domain-containing protein -
JZ655_RS10655 2215042..2215935 - 894 WP_207291734.1 siderophore-interacting protein -
JZ655_RS10660 2216093..2216464 + 372 WP_040075696.1 cupin domain-containing protein -
JZ655_RS10665 2216497..2217639 - 1143 WP_207291735.1 class C beta-lactamase -
JZ655_RS10670 2217878..2219212 - 1335 WP_207291736.1 HipA domain-containing protein Toxin
JZ655_RS10675 2219212..2219481 - 270 WP_207291737.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JZ655_RS10680 2219613..2221802 - 2190 WP_207291738.1 TonB-dependent siderophore receptor -
JZ655_RS10685 2222067..2222954 - 888 WP_207291739.1 LysR family transcriptional regulator -
JZ655_RS10690 2223075..2224172 + 1098 WP_207291740.1 NADH:flavin oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 49708.31 Da        Isoelectric Point: 9.1219

>T196253 WP_207291736.1 NZ_CP071383:c2219212-2217878 [Leclercia sp. 4-9-1-25]
MPKLVTWMNNERVGELTKLPNGAHTFKYDREWLYNRHARPISLSLPLQTGTLTSDAVFNFFDNLLPDSAVVRDRIVKRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPDAIISAPIMRWETLDEPRLEKVLSAYQADIPLGMIKDENDFRISVAGAQEKTAL
LQINDAWCIPKGITPTNHIIKLPIGEIRQPNATLDLRDSVDNEYFCLAFARALGLAVPDATIITAGQIRALAVERFDRRW
NADRTMLLRLPQEDMCQAFGLPSSLKYESDGGPGILPIMSFLLGSSEALQDRYHFMQFQLFQWLLAATDGHAKNFSVFIQ
PGGSYRLTPFYDILSAYPLLGGAGLHISDLKLAMGLKASRGRKNAIDRIYPRHFFALAKEVGFAQSEMERIMQTFAQQVP
DALRRVNDALPAGFSSRVAKTITAGVLRLHQRLVNGLSLTGYKY

Download         Length: 1335 bp

>T196253 NZ_CP095023:c2868650-2868255 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10317.78 Da        Isoelectric Point: 5.7832

>AT196253 WP_207291737.1 NZ_CP071383:c2219481-2219212 [Leclercia sp. 4-9-1-25]
MKPPMIYSPVQLANYLKLTRQKNNWTQSELARKIGIKQATVSNFENNPDNITLTTFFKLLQALELTMVLYDKGETVEDST
SIQHQDVEW

Download         Length: 270 bp

>AT196253 NZ_CP095023:c2868892-2868647 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References