Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1016764..1017383 Replicon chromosome
Accession NZ_CP071383
Organism Leclercia sp. 4-9-1-25

Toxin (Protein)


Gene name Hha Uniprot ID A0A0M3F8Q9
Locus tag JZ655_RS04735 Protein ID WP_040076875.1
Coordinates 1016764..1016982 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0M3F8E5
Locus tag JZ655_RS04740 Protein ID WP_046884434.1
Coordinates 1016991..1017383 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ655_RS04710 1013374..1013728 + 355 Protein_912 DUF1428 family protein -
JZ655_RS04715 1013771..1015330 - 1560 WP_207293121.1 EAL domain-containing protein -
JZ655_RS04720 1015550..1015810 + 261 WP_046884436.1 type B 50S ribosomal protein L31 -
JZ655_RS04725 1015813..1015953 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JZ655_RS04730 1016025..1016489 - 465 WP_040076876.1 YlaC family protein -
JZ655_RS04735 1016764..1016982 - 219 WP_040076875.1 hemolysin expression modulator Hha Toxin
JZ655_RS04740 1016991..1017383 - 393 WP_046884434.1 Hha toxicity modulator TomB Antitoxin
JZ655_RS04745 1017528..1018225 + 698 Protein_919 IS1 family transposase -
JZ655_RS04750 1018652..1021789 - 3138 WP_040076873.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T196252 WP_040076875.1 NZ_CP071383:c1016982-1016764 [Leclercia sp. 4-9-1-25]
MSEKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T196252 NZ_CP095023:2867388-2867765 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15156.96 Da        Isoelectric Point: 5.1531

>AT196252 WP_046884434.1 NZ_CP071383:c1017383-1016991 [Leclercia sp. 4-9-1-25]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDDSNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINSQDLQKWRKSGNRLFRCFVNASRANPLGSYVKTITNN

Download         Length: 393 bp

>AT196252 NZ_CP095023:2867134-2867391 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3F8Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M3F8E5

References