Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2472442..2473080 Replicon chromosome
Accession NZ_CP071375
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J0O73_RS11845 Protein ID WP_000813794.1
Coordinates 2472442..2472618 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J0O73_RS11850 Protein ID WP_001270286.1
Coordinates 2472664..2473080 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS11825 2468061..2469275 - 1215 WP_072169390.1 BenE family transporter YdcO -
J0O73_RS11830 2469328..2469864 + 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
J0O73_RS11835 2469937..2471898 + 1962 WP_207184267.1 DUF3656 domain-containing protein -
J0O73_RS11840 2471990..2472220 - 231 WP_000494244.1 YncJ family protein -
J0O73_RS11845 2472442..2472618 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
J0O73_RS11850 2472664..2473080 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
J0O73_RS11855 2473159..2474568 + 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
J0O73_RS11860 2474810..2475955 + 1146 WP_089637768.1 ABC transporter substrate-binding protein -
J0O73_RS11865 2475973..2476986 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
J0O73_RS11870 2476987..2477928 + 942 WP_053883752.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T196221 WP_000813794.1 NZ_CP071375:2472442-2472618 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T196221 NZ_CP095023:717964-718359 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT196221 WP_001270286.1 NZ_CP071375:2472664-2473080 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT196221 NZ_CP095023:717710-717964 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References