Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1251550..1252168 Replicon chromosome
Accession NZ_CP071375
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J0O73_RS05950 Protein ID WP_001291435.1
Coordinates 1251550..1251768 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J0O73_RS05955 Protein ID WP_000344800.1
Coordinates 1251794..1252168 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS05915 1246839..1247411 + 573 WP_000779831.1 YbaY family lipoprotein -
J0O73_RS05920 1247442..1247753 - 312 WP_000409911.1 MGMT family protein -
J0O73_RS05930 1248132..1248485 + 354 WP_000878140.1 DUF1428 domain-containing protein -
J0O73_RS05935 1248527..1250077 - 1551 WP_053883318.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J0O73_RS05940 1250241..1250711 - 471 WP_000136192.1 YlaC family protein -
J0O73_RS05945 1250827..1251378 - 552 WP_096220366.1 maltose O-acetyltransferase -
J0O73_RS05950 1251550..1251768 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
J0O73_RS05955 1251794..1252168 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J0O73_RS05960 1252714..1255863 - 3150 WP_053883285.1 efflux RND transporter permease AcrB -
J0O73_RS05965 1255886..1257079 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T196217 WP_001291435.1 NZ_CP071375:c1251768-1251550 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T196217 NZ_CP095023:c696546-696154 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT196217 WP_000344800.1 NZ_CP071375:c1252168-1251794 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT196217 NZ_CP095023:c696800-696543 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References