Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1038536..1039332 Replicon chromosome
Accession NZ_CP071326
Organism Photobacterium ganghwense strain C2.2

Toxin (Protein)


Gene name - Uniprot ID A0A0J1K069
Locus tag FH974_RS20840 Protein ID WP_047885761.1
Coordinates 1038536..1039066 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0J1H842
Locus tag FH974_RS20845 Protein ID WP_047885762.1
Coordinates 1039063..1039332 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH974_RS20820 1035030..1035923 - 894 WP_207103727.1 hypothetical protein -
FH974_RS20825 1036054..1037355 - 1302 WP_207103728.1 DUF4113 domain-containing protein -
FH974_RS20830 1037361..1037744 - 384 WP_047886305.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
FH974_RS20835 1038031..1038441 + 411 WP_047885760.1 SPOR domain-containing protein -
FH974_RS20840 1038536..1039066 - 531 WP_047885761.1 GNAT family N-acetyltransferase Toxin
FH974_RS20845 1039063..1039332 - 270 WP_047885762.1 DUF1778 domain-containing protein Antitoxin
FH974_RS20850 1039464..1040915 - 1452 WP_084712588.1 MATE family efflux transporter -
FH974_RS20855 1041091..1042068 + 978 WP_207103729.1 LysR family transcriptional regulator -
FH974_RS20860 1042112..1043044 - 933 WP_047885764.1 FAD-binding protein -
FH974_RS20865 1043044..1043793 - 750 WP_047885765.1 electron transfer flavoprotein subunit beta/FixA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(2-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19877.20 Da        Isoelectric Point: 9.6044

>T196213 WP_047885761.1 NZ_CP071326:c1039066-1038536 [Photobacterium ganghwense]
VSWSKTFVELDKHVHDRASFDCGEAELNTFIQTQASKHMQAGISRTMVLPASLPLLNQKWPICAFYSVAPSSIRRETLPV
SLAKKLPNYPIPVFLLAQLAVHREYHGHGLGKVSLIRALKYLWEVNAHMRAYAIVVDCLTPAAEAFYTKYGFQVLCDHNG
RTRMFIPMKTVGQLFS

Download         Length: 531 bp

>T196213 NZ_CP095023:365396-365821 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9922.18 Da        Isoelectric Point: 4.3216

>AT196213 WP_047885762.1 NZ_CP071326:c1039332-1039063 [Photobacterium ganghwense]
MATARLDLRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAQHESMTVQNDVFDRFMDACDKAEAPNQALRDAA
AFTEENGFK

Download         Length: 270 bp

>AT196213 NZ_CP095023:365178-365399 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1K069

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1H842

References