Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4214213..4214832 Replicon chromosome
Accession NZ_CP071324
Organism Klebsiella pneumoniae strain JS161205112

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J0G22_RS21280 Protein ID WP_002892050.1
Coordinates 4214213..4214431 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J0G22_RS21285 Protein ID WP_002892066.1
Coordinates 4214458..4214832 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G22_RS21245 4210222..4210485 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
J0G22_RS21250 4210485..4210625 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J0G22_RS21255 4210622..4211320 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
J0G22_RS21260 4211421..4212878 + 1458 WP_029883993.1 PLP-dependent aminotransferase family protein -
J0G22_RS21265 4212885..4213355 - 471 WP_002892026.1 YlaC family protein -
J0G22_RS21270 4213376..4213516 + 141 WP_004147370.1 hypothetical protein -
J0G22_RS21275 4213488..4214054 - 567 WP_002892030.1 maltose O-acetyltransferase -
J0G22_RS21280 4214213..4214431 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
J0G22_RS21285 4214458..4214832 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J0G22_RS21290 4215318..4218464 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
J0G22_RS21295 4218487..4219680 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T196212 WP_002892050.1 NZ_CP071324:c4214431-4214213 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T196212 NZ_CP095023:364828-365130 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT196212 WP_002892066.1 NZ_CP071324:c4214832-4214458 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT196212 NZ_CP095023:365178-365399 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References