Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2115002..2115659 Replicon chromosome
Accession NZ_CP071324
Organism Klebsiella pneumoniae strain JS161205112

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J0G22_RS11215 Protein ID WP_002916310.1
Coordinates 2115002..2115412 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J0G22_RS11220 Protein ID WP_002916312.1
Coordinates 2115393..2115659 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G22_RS11195 2111002..2112735 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
J0G22_RS11200 2112741..2113454 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J0G22_RS11205 2113477..2114373 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J0G22_RS11210 2114474..2114995 + 522 WP_002916308.1 flavodoxin FldB -
J0G22_RS11215 2115002..2115412 - 411 WP_002916310.1 protein YgfX Toxin
J0G22_RS11220 2115393..2115659 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J0G22_RS11225 2115905..2116888 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J0G22_RS11230 2116987..2117646 - 660 WP_002916317.1 hemolysin III family protein -
J0G22_RS11235 2117810..2118121 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J0G22_RS11240 2118171..2118899 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J0G22_RS11245 2119018..2120451 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T196205 WP_002916310.1 NZ_CP071324:c2115412-2115002 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T196205 NZ_CP095022:3548717-3549061 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT196205 WP_002916312.1 NZ_CP071324:c2115659-2115393 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196205 NZ_CP095022:3549058-3549387 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References