Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4974510..4975045 Replicon chromosome
Accession NZ_CP071320
Organism Serratia ureilytica strain T6

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J0X03_RS23535 Protein ID WP_147880991.1
Coordinates 4974510..4974785 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8G2GBD7
Locus tag J0X03_RS23540 Protein ID WP_033639076.1
Coordinates 4974785..4975045 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X03_RS23515 4970328..4971320 - 993 WP_160203880.1 acyltransferase -
J0X03_RS23520 4971538..4972785 + 1248 WP_033633516.1 MFS transporter -
J0X03_RS23525 4972839..4973465 - 627 WP_033645107.1 LysE family translocator -
J0X03_RS23530 4973587..4974498 + 912 WP_033645108.1 LysR family transcriptional regulator -
J0X03_RS23535 4974510..4974785 - 276 WP_147880991.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0X03_RS23540 4974785..4975045 - 261 WP_033639076.1 ribbon-helix-helix domain-containing protein Antitoxin
J0X03_RS23545 4975128..4976969 - 1842 WP_160203879.1 selenocysteine-specific translation elongation factor -
J0X03_RS23550 4976966..4978360 - 1395 WP_033645110.1 L-seryl-tRNA(Sec) selenium transferase -
J0X03_RS23555 4978430..4979035 - 606 WP_033645111.1 glutathione S-transferase -
J0X03_RS23560 4979076..4979726 - 651 WP_033645112.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4966538..4975045 8507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10620.42 Da        Isoelectric Point: 10.3377

>T196192 WP_147880991.1 NZ_CP071320:c4974785-4974510 [Serratia ureilytica]
MELKWTSKALPDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQMQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T196192 NZ_CP095022:c2851754-2851335 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9682.01 Da        Isoelectric Point: 4.5317

>AT196192 WP_033639076.1 NZ_CP071320:c4975045-4974785 [Serratia ureilytica]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Download         Length: 261 bp

>AT196192 NZ_CP095022:c2851975-2851751 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References