Detailed information of TA system TA196191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4856634..4857106
• Replicon: chromosome
• Accession: NZ_CP071320
• Organism: Serratia ureilytica strain T6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8B4GM79
• Locus tag: J0X03_RS22990
• Protein ID: WP_033645001.1
• Coordinates: 4856634..4856909 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J0X03_RS22995
• Protein ID: WP_033645226.1
• Coordinates: 4856909..4857106 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0X03_RS22975	4851680..4852057	-	378	WP_025304893.1	AprI/Inh family metalloprotease inhibitor	-
J0X03_RS22980	4852112..4853575	-	1464	WP_033652421.1	serralysin family metalloprotease	-
J0X03_RS22985	4854256..4856574	+	2319	WP_160203891.1	zinc/cadmium/mercury/lead-transporting ATPase	-
J0X03_RS22990	4856634..4856909	-	276	WP_033645001.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J0X03_RS22995	4856909..4857106	-	198	WP_033645226.1	hypothetical protein	Antitoxin
J0X03_RS23000	4857171..4857416	-	246	WP_025304890.1	sulfurtransferase TusA	-
J0X03_RS23005	4857638..4858297	+	660	WP_033652423.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
J0X03_RS23010	4858339..4858773	+	435	WP_047025951.1	GNAT family N-acetyltransferase	-
J0X03_RS23015	4858854..4859417	+	564	WP_025304887.1	DcrB family lipoprotein	-
J0X03_RS23020	4859452..4860651	-	1200	WP_160203890.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
J0X03_RS23025	4860648..4861916	-	1269	WP_038874127.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10682.57 Da
• Isoelectric Point: 11.2806

>T196191 WP_033645001.1 NZ_CP071320:c4856909-4856634 [Serratia ureilytica]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVTPAARHPRIFRRGRVDGTHEIPLHPHYLLIYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T196191 NZ_CP095022:2805384-2805809 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7395.40 Da
• Isoelectric Point: 4.1359

>AT196191 WP_033645226.1 NZ_CP071320:c4857106-4856909 [Serratia ureilytica]
MSILLLPTVAKMENEEHTQGYERWFLERVQEAMDEPWPGIPHDDVMAEMDAVIAAAEARINAKQA

Nucleotide

• Length: 198 bp

>AT196191 NZ_CP095022:2805157-2805378 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Structures

Toxin

• AlphaFold DB: A0A8B4GM79