Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3930701..3931323 Replicon chromosome
Accession NZ_CP071320
Organism Serratia ureilytica strain T6

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag J0X03_RS18545 Protein ID WP_004940313.1
Coordinates 3931120..3931323 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag J0X03_RS18540 Protein ID WP_004940312.1
Coordinates 3930701..3931069 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X03_RS18510 3926797..3927051 + 255 WP_004940303.1 type B 50S ribosomal protein L31 -
J0X03_RS18515 3927064..3927204 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
J0X03_RS18520 3927310..3928188 - 879 WP_033642106.1 metal ABC transporter substrate-binding protein -
J0X03_RS18525 3928214..3929071 - 858 WP_033642105.1 metal ABC transporter permease -
J0X03_RS18530 3929068..3929781 - 714 WP_033642104.1 ABC transporter ATP-binding protein -
J0X03_RS18535 3930188..3930541 + 354 WP_033642103.1 hypothetical protein -
J0X03_RS18540 3930701..3931069 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
J0X03_RS18545 3931120..3931323 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
J0X03_RS18550 3931605..3932123 - 519 WP_033651103.1 cytochrome b/b6 domain-containing protein -
J0X03_RS18555 3932176..3933603 - 1428 WP_096241962.1 N-acetylglucosamine-binding protein GbpA -
J0X03_RS18560 3933861..3934223 + 363 WP_052752709.1 type II secretion system pilot lipoprotein GspS -
J0X03_RS18565 3934220..3935035 - 816 WP_160204025.1 A24 family peptidase -
J0X03_RS18570 3935020..3935514 - 495 WP_046688369.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T196190 WP_004940313.1 NZ_CP071320:3931120-3931323 [Serratia ureilytica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T196190 NZ_CP095022:c2402910-2402593 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT196190 WP_004940312.1 NZ_CP071320:3930701-3931069 [Serratia ureilytica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT196190 NZ_CP095022:c2403122-2402907 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References