Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3298773..3299298 Replicon chromosome
Accession NZ_CP071320
Organism Serratia ureilytica strain T6

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag J0X03_RS15475 Protein ID WP_033633469.1
Coordinates 3299014..3299298 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag J0X03_RS15470 Protein ID WP_004928423.1
Coordinates 3298773..3299024 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0X03_RS15440 3294045..3294587 + 543 WP_033642535.1 lipoprotein -
J0X03_RS15445 3294852..3295580 + 729 WP_089192582.1 arginine ABC transporter ATP-binding protein ArtP -
J0X03_RS15450 3295613..3296344 + 732 WP_033642533.1 arginine ABC transporter substrate-binding protein -
J0X03_RS15455 3296354..3297070 + 717 WP_025159684.1 arginine ABC transporter permease ArtQ -
J0X03_RS15460 3297070..3297738 + 669 WP_099783622.1 arginine ABC transporter permease ArtM -
J0X03_RS15465 3297937..3298671 + 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
J0X03_RS15470 3298773..3299024 + 252 WP_004928423.1 prevent-host-death protein Antitoxin
J0X03_RS15475 3299014..3299298 + 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0X03_RS15480 3299295..3300422 - 1128 WP_160204142.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
J0X03_RS15485 3300491..3300970 - 480 WP_047024958.1 YbjO family protein -
J0X03_RS15490 3301132..3301977 - 846 WP_042784088.1 putrescine ABC transporter permease PotI -
J0X03_RS15495 3301974..3302936 - 963 WP_042784087.1 putrescine ABC transporter permease PotH -
J0X03_RS15500 3302961..3304094 - 1134 WP_160204141.1 putrescine ABC transporter ATP-binding subunit PotG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T196189 WP_033633469.1 NZ_CP071320:3299014-3299298 [Serratia ureilytica]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T196189 NZ_CP095022:c2363506-2363072 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT196189 WP_004928423.1 NZ_CP071320:3298773-3299024 [Serratia ureilytica]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT196189 NZ_CP095022:c2363767-2363513 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References