Detailed information of TA system TA196178

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 842725..843394
• Replicon: chromosome
• Accession: NZ_CP071320
• Organism: Serratia ureilytica strain T6

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: J0X03_RS03885
• Protein ID: WP_160204552.1
• Coordinates: 842972..843394 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: J0X03_RS03880
• Protein ID: WP_019455657.1
• Coordinates: 842725..842991 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0X03_RS03855	838292..839218	+	927	WP_033644768.1	ribokinase	-
J0X03_RS03860	839259..839867	-	609	WP_047573791.1	HD domain-containing protein	-
J0X03_RS03865	840051..840725	+	675	WP_033644772.1	hemolysin III family protein	-
J0X03_RS03870	840876..841373	+	498	WP_033644774.1	DUF2165 domain-containing protein	-
J0X03_RS03875	841412..842404	-	993	WP_047573794.1	tRNA-modifying protein YgfZ	-
J0X03_RS03880	842725..842991	+	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
J0X03_RS03885	842972..843394	+	423	WP_160204552.1	protein YgfX	Toxin
J0X03_RS03890	843394..844089	+	696	WP_047573795.1	two-component system response regulator CreB	-
J0X03_RS03895	844086..845504	+	1419	WP_160204551.1	two-component system sensor histidine kinase CreC	-
J0X03_RS03900	845585..846949	+	1365	WP_047573801.1	cell envelope integrity protein CreD	-
J0X03_RS03905	846987..847505	-	519	WP_033635825.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16426.42 Da
• Isoelectric Point: 10.6021

>T196178 WP_160204552.1 NZ_CP071320:842972-843394 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWQLAKKPWMPGYGLLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEEA

Nucleotide

• Length: 423 bp

>T196178 NZ_CP095022:1768269-1768673 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT196178 WP_019455657.1 NZ_CP071320:842725-842991 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT196178 NZ_CP095022:1768060-1768263 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04