Detailed information of TA system TA196174

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1253999..1254635
• Replicon: chromosome
• Accession: NZ_CP071319
• Organism: Acinetobacter indicus strain GXNN62X4

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9KY14
• Locus tag: J0W33_RS05930
• Protein ID: WP_005180237.1
• Coordinates: 1253999..1254391 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9KY84
• Locus tag: J0W33_RS05935
• Protein ID: WP_005180238.1
• Coordinates: 1254378..1254635 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0W33_RS05910	1249324..1251600	-	2277	WP_206896980.1	TRAP transporter large permease subunit	-
J0W33_RS05915	1251781..1252353	-	573	WP_168393915.1	rhombosortase	-
J0W33_RS05920	1252409..1253482	-	1074	WP_163145409.1	hypothetical protein	-
J0W33_RS05925	1253672..1253851	+	180	WP_127801044.1	hypothetical protein	-
J0W33_RS05930	1253999..1254391	-	393	WP_005180237.1	hypothetical protein	Toxin
J0W33_RS05935	1254378..1254635	-	258	WP_005180238.1	succinate dehydrogenase assembly factor 2	Antitoxin
J0W33_RS05940	1254819..1255991	+	1173	WP_075167404.1	acyl-CoA dehydrogenase family protein	-
J0W33_RS05945	1256079..1257569	-	1491	WP_005180241.1	NAD(P)/FAD-dependent oxidoreductase	-
J0W33_RS05950	1257768..1258133	-	366	WP_004754212.1	50S ribosomal protein L17	-
J0W33_RS05955	1258153..1259160	-	1008	WP_005180245.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14930.64 Da
• Isoelectric Point: 10.4540

>T196174 WP_005180237.1 NZ_CP071319:c1254391-1253999 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Nucleotide

• Length: 393 bp

>T196174 NZ_CP095022:c1388883-1388590 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10220.62 Da
• Isoelectric Point: 4.6150

>AT196174 WP_005180238.1 NZ_CP071319:c1254635-1254378 [Acinetobacter indicus]
MSEDISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT196174 NZ_CP095022:c1389149-1388880 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: N9KY14

Antitoxin

• AlphaFold DB: N9KY84