Detailed information of TA system TA196173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 233873..234988
• Replicon: chromosome
• Accession: NZ_CP071319
• Organism: Acinetobacter indicus strain GXNN62X4

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: J0W33_RS01120
• Protein ID: WP_016658124.1
• Coordinates: 234824..234988 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: J0W33_RS01115
• Protein ID: WP_206896865.1
• Coordinates: 233873..234742 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0W33_RS01085	229339..229788	+	450	WP_005178047.1	cyanase	-
J0W33_RS01090	229978..230268	-	291	WP_168381777.1	KGG domain-containing protein	-
J0W33_RS01095	230635..231105	-	471	WP_004809604.1	IS5/IS1182 family transposase	-
J0W33_RS01100	231053..231448	-	396	WP_008306679.1	transposase family protein	-
J0W33_RS01105	231631..232872	-	1242	WP_206896864.1	MFS transporter	-
J0W33_RS01110	233531..233770	+	240	WP_104471337.1	DUF2171 domain-containing protein	-
J0W33_RS01115	233873..234742	+	870	WP_206896865.1	SDR family oxidoreductase	Antitoxin
J0W33_RS01120	234824..234988	+	165	WP_016658124.1	hypothetical protein	Toxin
J0W33_RS01125	235088..236506	-	1419	WP_206896866.1	iron-containing redox enzyme family protein	-
J0W33_RS01130	236807..237964	-	1158	WP_206897018.1	fatty acid desaturase	-
J0W33_RS01135	237988..239010	-	1023	WP_168396059.1	ferredoxin reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T196173 WP_016658124.1 NZ_CP071319:234824-234988 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T196173 NZ_CP095022:1384545-1384976 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31905.02 Da
• Isoelectric Point: 4.9636

>AT196173 WP_206896865.1 NZ_CP071319:233873-234742 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNQLIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT196173 NZ_CP095022:1384288-1384548 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: V2U6R6