Detailed information of TA system TA196170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 222756..223871
• Replicon: chromosome
• Accession: NZ_CP071317
• Organism: Acinetobacter indicus strain GXNN15X4

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: J0W32_RS01050
• Protein ID: WP_016658124.1
• Coordinates: 223707..223871 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: J0W32_RS01045
• Protein ID: WP_005178053.1
• Coordinates: 222756..223625 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0W32_RS01020	218045..218854	-	810	WP_005178046.1	formate/nitrite transporter family protein	-
J0W32_RS01025	219147..219596	+	450	WP_005178047.1	cyanase	-
J0W32_RS01030	219785..220075	-	291	WP_168381777.1	KGG domain-containing protein	-
J0W32_RS01035	220513..221754	-	1242	WP_180057682.1	MFS transporter	-
J0W32_RS01040	222413..222652	+	240	WP_104471337.1	DUF2171 domain-containing protein	-
J0W32_RS01045	222756..223625	+	870	WP_005178053.1	SDR family oxidoreductase	Antitoxin
J0W32_RS01050	223707..223871	+	165	WP_016658124.1	hypothetical protein	Toxin
J0W32_RS01055	223970..225388	-	1419	WP_180057679.1	iron-containing redox enzyme family protein	-
J0W32_RS01060	225690..226847	-	1158	WP_206862939.1	fatty acid desaturase	-
J0W32_RS01065	226871..227893	-	1023	WP_206862791.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T196170 WP_016658124.1 NZ_CP071317:223707-223871 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T196170 NZ_CP095022:1013458-1013892 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31879.96 Da
• Isoelectric Point: 4.8531

>AT196170 WP_005178053.1 NZ_CP071317:222756-223625 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQAGDSIINTTSITSYQGHNELIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT196170 NZ_CP095022:1013273-1013452 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Toxin

• AlphaFold DB: V2U6R6