Detailed information of TA system TA196165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 378756..379236
• Replicon: chromosome
• Accession: NZ_CP071311
• Organism: Rhizobium sp. X9

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: JZY08_RS01850
• Protein ID: WP_035241660.1
• Coordinates: 378756..379025 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7L5BG61
• Locus tag: JZY08_RS01855
• Protein ID: WP_003494062.1
• Coordinates: 379009..379236 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY08_RS01815	373770..374399	+	630	WP_003494042.1	DNA-3-methyladenine glycosylase I	-
JZY08_RS01820	374396..374839	+	444	WP_216330784.1	hypothetical protein	-
JZY08_RS01825	374852..375895	-	1044	WP_216330786.1	YeiH family protein	-
JZY08_RS01830	375977..376894	+	918	WP_003494048.1	LysR substrate-binding domain-containing protein	-
JZY08_RS01835	377112..377486	-	375	WP_003494050.1	DUF305 domain-containing protein	-
JZY08_RS01840	377545..377943	-	399	WP_253204039.1	hypothetical protein	-
JZY08_RS01845	377985..378749	-	765	WP_216330788.1	hypothetical protein	-
JZY08_RS01850	378756..379025	-	270	WP_035241660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JZY08_RS01855	379009..379236	-	228	WP_003494062.1	DUF6290 family protein	Antitoxin
JZY08_RS01860	379393..380916	+	1524	WP_216330790.1	histidine--tRNA ligase	-
JZY08_RS01865	380921..381289	+	369	WP_003494067.1	VOC family protein	-
JZY08_RS01870	381307..382434	+	1128	WP_137038579.1	ATP phosphoribosyltransferase regulatory subunit	-
JZY08_RS01875	382431..383123	+	693	WP_003494071.1	ATP phosphoribosyltransferase	-
JZY08_RS01880	383188..383634	-	447	WP_216330792.1	DoxX family protein	-
JZY08_RS01885	383791..384210	-	420	WP_246231221.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (6-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10755.47 Da
• Isoelectric Point: 9.9415

>T196165 WP_035241660.1 NZ_CP071311:c379025-378756 [Rhizobium sp. X9]
VIWTIEYHTLVQKEMRKLNPEIRRRIRAFLHERLAVLDDPRQTGSALQGSELGNFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Nucleotide

• Length: 270 bp

>T196165 NZ_CP095022:c752254-751871 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8803.88 Da
• Isoelectric Point: 4.6909

>AT196165 WP_003494062.1 NZ_CP071311:c379236-379009 [Rhizobium sp. X9]
MSKQTAIRLPDETYERLKALSARTGRTSAFYIREAIEKHIEDMEDLYLAEEAVRQIQRGEAKVISAEEFWRDLDN

Nucleotide

• Length: 228 bp

>AT196165 NZ_CP095022:c752504-752349 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7L5BG61