Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1431464..1431950 | Replicon | chromosome |
Accession | NZ_CP071305 | ||
Organism | Streptococcus suis strain SC183 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0Z8G620 |
Locus tag | JZY07_RS07120 | Protein ID | WP_024385504.1 |
Coordinates | 1431464..1431733 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D5AGV1 |
Locus tag | JZY07_RS07125 | Protein ID | WP_002938604.1 |
Coordinates | 1431723..1431950 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JZY07_RS07100 | 1427350..1428324 | - | 975 | WP_014736012.1 | YvcK family protein | - |
JZY07_RS07105 | 1428321..1429208 | - | 888 | WP_024412169.1 | RNase adapter RapZ | - |
JZY07_RS07110 | 1429230..1429607 | - | 378 | WP_024412168.1 | RidA family protein | - |
JZY07_RS07115 | 1429791..1431110 | - | 1320 | WP_024412167.1 | MATE family efflux transporter | - |
JZY07_RS07120 | 1431464..1431733 | - | 270 | WP_024385504.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JZY07_RS07125 | 1431723..1431950 | - | 228 | WP_002938604.1 | hypothetical protein | Antitoxin |
JZY07_RS07130 | 1432166..1433512 | - | 1347 | WP_024377171.1 | asparagine--tRNA ligase | - |
JZY07_RS07135 | 1433526..1434707 | - | 1182 | WP_024412166.1 | pyridoxal phosphate-dependent aminotransferase | - |
JZY07_RS07140 | 1434704..1435201 | - | 498 | WP_024412165.1 | DUF5590 domain-containing protein | - |
JZY07_RS07145 | 1435415..1435864 | + | 450 | WP_206974737.1 | MarR family transcriptional regulator | - |
JZY07_RS07150 | 1435903..1436766 | - | 864 | WP_105141859.1 | IS982 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10463.52 Da Isoelectric Point: 10.3192
>T196163 WP_024385504.1 NZ_CP071305:c1431733-1431464 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GYRKEIYKK
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GYRKEIYKK
Download Length: 270 bp
>T196163 NZ_CP095022:715018-715413 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8450.51 Da Isoelectric Point: 4.1589
>AT196163 WP_002938604.1 NZ_CP071305:c1431950-1431723 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
Download Length: 228 bp
>AT196163 NZ_CP095022:714764-715018 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8G620 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140EXF0 |