Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1431464..1431950 Replicon chromosome
Accession NZ_CP071305
Organism Streptococcus suis strain SC183

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8G620
Locus tag JZY07_RS07120 Protein ID WP_024385504.1
Coordinates 1431464..1431733 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag JZY07_RS07125 Protein ID WP_002938604.1
Coordinates 1431723..1431950 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZY07_RS07100 1427350..1428324 - 975 WP_014736012.1 YvcK family protein -
JZY07_RS07105 1428321..1429208 - 888 WP_024412169.1 RNase adapter RapZ -
JZY07_RS07110 1429230..1429607 - 378 WP_024412168.1 RidA family protein -
JZY07_RS07115 1429791..1431110 - 1320 WP_024412167.1 MATE family efflux transporter -
JZY07_RS07120 1431464..1431733 - 270 WP_024385504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZY07_RS07125 1431723..1431950 - 228 WP_002938604.1 hypothetical protein Antitoxin
JZY07_RS07130 1432166..1433512 - 1347 WP_024377171.1 asparagine--tRNA ligase -
JZY07_RS07135 1433526..1434707 - 1182 WP_024412166.1 pyridoxal phosphate-dependent aminotransferase -
JZY07_RS07140 1434704..1435201 - 498 WP_024412165.1 DUF5590 domain-containing protein -
JZY07_RS07145 1435415..1435864 + 450 WP_206974737.1 MarR family transcriptional regulator -
JZY07_RS07150 1435903..1436766 - 864 WP_105141859.1 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10463.52 Da        Isoelectric Point: 10.3192

>T196163 WP_024385504.1 NZ_CP071305:c1431733-1431464 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GYRKEIYKK

Download         Length: 270 bp

>T196163 NZ_CP095022:715018-715413 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT196163 WP_002938604.1 NZ_CP071305:c1431950-1431723 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT196163 NZ_CP095022:714764-715018 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8G620

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References