Detailed information of TA system TA196162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1088512..1089007
• Replicon: chromosome
• Accession: NZ_CP071305
• Organism: Streptococcus suis strain SC183

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JZY07_RS05485
• Protein ID: WP_024412110.1
• Coordinates: 1088741..1089007 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A123SEG2
• Locus tag: JZY07_RS05480
• Protein ID: WP_015646833.1
• Coordinates: 1088512..1088751 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY07_RS05450	1084164..1084301	+	138	WP_169050553.1	hypothetical protein	-
JZY07_RS05455	1084314..1085048	+	735	WP_024412114.1	beta-carotene 15,15'-monooxygenase	-
JZY07_RS05460	1085147..1085287	+	141	WP_032497796.1	hypothetical protein	-
JZY07_RS05465	1085300..1085689	+	390	WP_024412113.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
JZY07_RS05470	1085698..1086450	+	753	WP_024412112.1	ABC transporter ATP-binding protein	-
JZY07_RS05475	1086451..1088421	+	1971	WP_024412111.1	FtsX-like permease family protein	-
JZY07_RS05480	1088512..1088751	+	240	WP_015646833.1	hypothetical protein	Antitoxin
JZY07_RS05485	1088741..1089007	+	267	WP_024412110.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JZY07_RS05490	1089046..1089714	+	669	WP_024412109.1	response regulator transcription factor	-
JZY07_RS05495	1089711..1090652	+	942	WP_024412108.1	sensor histidine kinase	-
JZY07_RS05500	1090728..1092236	+	1509	WP_024412107.1	phosphoglucomutase	-
JZY07_RS05505	1092299..1093369	-	1071	WP_024412106.1	tyrosine recombinase XerS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / lsa(E) / lnu(B) / aph(3')-III / cat / erm(B)	-	1036462..1128323	91861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10190.87 Da
• Isoelectric Point: 10.3339

>T196162 WP_024412110.1 NZ_CP071305:1088741-1089007 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANSSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Nucleotide

• Length: 267 bp

>T196162 NZ_CP095022:709360-709761 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8879.09 Da
• Isoelectric Point: 3.7832

>AT196162 WP_015646833.1 NZ_CP071305:1088512-1088751 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT196162 NZ_CP095022:709136-709363 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A123SEG2