196155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 137153..137904 Replicon plasmid pSA-KpST14-NDM-1
Accession NZ_CP071280
Organism Klebsiella pneumoniae subsp. pneumoniae strain SA-KpST14

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag JZ794_RS26640 Protein ID WP_014386536.1
Coordinates 137422..137904 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag JZ794_RS26635 Protein ID WP_004902250.1
Coordinates 137153..137431 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZ794_RS26600 132796..133221 - 426 WP_000522996.1 organomercurial transporter MerC -
JZ794_RS26605 133249..133524 - 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
JZ794_RS26610 133540..133905 - 366 WP_004200999.1 mercuric ion transporter MerT -
JZ794_RS26615 133977..134432 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
JZ794_RS26620 135085..135543 + 459 WP_014386535.1 hypothetical protein -
JZ794_RS26625 136373..136714 + 342 WP_004902257.1 hypothetical protein -
JZ794_RS26630 136822..137034 + 213 WP_004902255.1 hypothetical protein -
JZ794_RS26635 137153..137431 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
JZ794_RS26640 137422..137904 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
JZ794_RS26645 138226..139839 - 1614 WP_000080200.1 IS66-like element ISEc23 family transposase -
JZ794_RS26650 139870..140220 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
JZ794_RS26655 140217..140642 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
JZ794_RS26660 141479..142018 + 540 WP_004902239.1 hypothetical protein -
JZ794_RS26665 142123..142515 + 393 WP_032442757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..269326 269326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T196155 WP_014386536.1 NZ_CP071280:137422-137904 [Klebsiella pneumoniae subsp. pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T196155 NZ_CP095022:362458-362883 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT196155 WP_004902250.1 NZ_CP071280:137153-137431 [Klebsiella pneumoniae subsp. pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT196155 NZ_CP095022:362240-362461 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References