Detailed information of TA system TA196138

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 480566..481223
• Replicon: chromosome
• Accession: NZ_CP071279
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain SA-KpST14

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JZ794_RS02480
• Protein ID: WP_004181233.1
• Coordinates: 480813..481223 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: JZ794_RS02475
• Protein ID: WP_002916312.1
• Coordinates: 480566..480832 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ794_RS02450	475722..477155	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
JZ794_RS02455	477274..478002	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
JZ794_RS02460	478052..478363	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
JZ794_RS02465	478527..479186	+	660	WP_002916317.1	hemolysin III family protein	-
JZ794_RS02470	479337..480320	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
JZ794_RS02475	480566..480832	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
JZ794_RS02480	480813..481223	+	411	WP_004181233.1	protein YgfX	Toxin
JZ794_RS02485	481230..481751	-	522	WP_004144730.1	flavodoxin FldB	-
JZ794_RS02490	481852..482748	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
JZ794_RS02495	482771..483484	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JZ794_RS02500	483490..485223	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T196138 WP_004181233.1 NZ_CP071279:480813-481223 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T196138 NZ_CP095021:2920860-2921300 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT196138 WP_002916312.1 NZ_CP071279:480566-480832 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT196138 NZ_CP095021:2920586-2920873 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41