Detailed information of TA system TA196120

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1186203..1186875
• Replicon: chromosome
• Accession: NZ_CP071265
• Organism: Citrobacter freundii strain MEI002

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: J0G25_RS05690
• Protein ID: WP_250351761.1
• Coordinates: 1186203..1186532 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: J0G25_RS05695
• Protein ID: WP_199995266.1
• Coordinates: 1186558..1186875 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0G25_RS05685 (1181986)	1181986..1185528	-	3543	WP_044699589.1	inverse autotransporter beta domain-containing protein	-
J0G25_RS05690 (1186203)	1186203..1186532	-	330	WP_250351761.1	TA system toxin CbtA family protein	Toxin
J0G25_RS05695 (1186558)	1186558..1186875	-	318	WP_199995266.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J0G25_RS05700 (1186894)	1186894..1187081	-	188	Protein_1118	DUF987 family protein	-
J0G25_RS05705 (1187078)	1187078..1187554	-	477	WP_199995265.1	RadC family protein	-
J0G25_RS05710 (1187570)	1187570..1187959	-	390	Protein_1120	antirestriction protein	-
J0G25_RS05715 (1188984)	1188984..1189577	-	594	WP_038422871.1	hypothetical protein	-
J0G25_RS05720 (1189574)	1189574..1190011	-	438	WP_038422872.1	diadenylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12303.30 Da
• Isoelectric Point: 8.0276

>T196120 WP_250351761.1 NZ_CP071265:c1186532-1186203 [Citrobacter freundii]
MKTLPAIAQRAAKTCPPPVVIWQTLLARLLETHYGLTLPDTPFSDETLIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T196120 NZ_CP095021:1769631-1770035 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11823.43 Da
• Isoelectric Point: 6.6281

>AT196120 WP_199995266.1 NZ_CP071265:c1186875-1186558 [Citrobacter freundii]
MSNITWGLQRDITPRLGARLVQEGNQLHYLADRGSITGKFSNAECLKLDEAFPLFIRQMESILTTGELNPRHSHCIALYH
NGFTCEADTLGSHGYVYIVIYPTQP

Nucleotide

• Length: 318 bp

>AT196120 NZ_CP095021:1769422-1769625 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA