Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3559292..3559887 Replicon chromosome
Accession NZ_CP071263
Organism Escherichia coli strain MEI003

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag J0G23_RS17255 Protein ID WP_000239581.1
Coordinates 3559537..3559887 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID V0YZQ7
Locus tag J0G23_RS17250 Protein ID WP_001223206.1
Coordinates 3559292..3559543 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G23_RS17240 (3554957) 3554957..3558736 + 3780 WP_024229553.1 autotransporter assembly complex protein TamB -
J0G23_RS17245 (3558739) 3558739..3559080 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J0G23_RS17250 (3559292) 3559292..3559543 + 252 WP_001223206.1 type II toxin-antitoxin system ChpS family antitoxin Antitoxin
J0G23_RS17255 (3559537) 3559537..3559887 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
J0G23_RS17260 (3559966) 3559966..3560496 - 531 WP_000055075.1 inorganic diphosphatase -
J0G23_RS17265 (3560806) 3560806..3561762 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J0G23_RS17270 (3561895) 3561895..3563397 + 1503 WP_250375821.1 sugar ABC transporter ATP-binding protein -
J0G23_RS17275 (3563411) 3563411..3564433 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T196108 WP_000239581.1 NZ_CP071263:3559537-3559887 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T196108 NZ_CP095021:c753906-753598 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.62 Da        Isoelectric Point: 4.6509

>AT196108 WP_001223206.1 NZ_CP071263:3559292-3559543 [Escherichia coli]
MRITIKKWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT196108 NZ_CP095021:c754138-753893 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB V0YZQ7

References