Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2628616..2629247 Replicon chromosome
Accession NZ_CP071263
Organism Escherichia coli strain MEI003

Toxin (Protein)


Gene name hicA Uniprot ID A0A792T3R5
Locus tag J0G23_RS12990 Protein ID WP_001260302.1
Coordinates 2628972..2629247 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag J0G23_RS12985 Protein ID WP_000593555.1
Coordinates 2628616..2628975 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G23_RS12955 (2623729) 2623729..2624202 + 474 WP_001306344.1 PTS sugar transporter subunit IIA -
J0G23_RS12960 (2624199) 2624199..2624480 + 282 WP_000084021.1 PTS sugar transporter subunit IIB -
J0G23_RS12965 (2624557) 2624557..2625915 + 1359 WP_001306345.1 PTS galactitol transporter subunit IIC -
J0G23_RS12970 (2625908) 2625908..2627416 + 1509 WP_024229777.1 FGGY-family carbohydrate kinase -
J0G23_RS12975 (2627406) 2627406..2627675 + 270 WP_024229778.1 HPr family phosphocarrier protein -
J0G23_RS12980 (2627706) 2627706..2628566 + 861 WP_024229779.1 class II aldolase -
J0G23_RS12985 (2628616) 2628616..2628975 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J0G23_RS12990 (2628972) 2628972..2629247 - 276 WP_001260302.1 type II toxin-antitoxin system HicA family toxin Toxin
J0G23_RS12995 (2629320) 2629320..2630444 - 1125 WP_001314210.1 ABC transporter permease -
J0G23_RS13000 (2630444) 2630444..2633179 - 2736 WP_000149141.1 ribosome-associated ATPase/putative transporter RbbA -
J0G23_RS13005 (2633176) 2633176..2634243 - 1068 WP_000361507.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10177.85 Da        Isoelectric Point: 10.6128

>T196099 WP_001260302.1 NZ_CP071263:c2629247-2628972 [Escherichia coli]
MRTQVQALRKKQKNTLDQIVKSHVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T196099 NZ_CP095021:c639026-638613 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT196099 WP_000593555.1 NZ_CP071263:c2628975-2628616 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT196099 NZ_CP095021:c639289-639023 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A792T3R5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References