Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2105160..2105944 | Replicon | chromosome |
| Accession | NZ_CP071263 | ||
| Organism | Escherichia coli strain MEI003 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | C7BUQ8 |
| Locus tag | J0G23_RS10370 | Protein ID | WP_000854717.1 |
| Coordinates | 2105618..2105944 (+) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | C7BUQ9 |
| Locus tag | J0G23_RS10365 | Protein ID | WP_001285644.1 |
| Coordinates | 2105160..2105528 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0G23_RS10330 (2101724) | 2101724..2102179 | + | 456 | WP_000581504.1 | IrmA family protein | - |
| J0G23_RS10335 (2102258) | 2102258..2102491 | + | 234 | WP_000929560.1 | DUF905 family protein | - |
| J0G23_RS10340 (2102591) | 2102591..2103409 | + | 819 | WP_064577759.1 | DUF932 domain-containing protein | - |
| J0G23_RS10345 (2103409) | 2103409..2103654 | + | 246 | WP_024230327.1 | hypothetical protein | - |
| J0G23_RS10350 (2103748) | 2103748..2104221 | + | 474 | WP_001368734.1 | antirestriction protein | - |
| J0G23_RS10355 (2104237) | 2104237..2104713 | + | 477 | WP_001368782.1 | RadC family protein | - |
| J0G23_RS10360 (2104776) | 2104776..2104997 | + | 222 | WP_000692319.1 | DUF987 domain-containing protein | - |
| J0G23_RS10365 (2105160) | 2105160..2105528 | + | 369 | WP_001285644.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| J0G23_RS10370 (2105618) | 2105618..2105944 | + | 327 | WP_000854717.1 | TA system toxin CbtA family protein | Toxin |
| J0G23_RS10375 (2106045) | 2106045..2106479 | + | 435 | WP_000532709.1 | DUF5983 family protein | - |
| J0G23_RS10380 (2106491) | 2106491..2106688 | + | 198 | WP_000839233.1 | DUF957 domain-containing protein | - |
| J0G23_RS10385 (2106773) | 2106773..2107615 | + | 843 | WP_001382663.1 | DUF4942 domain-containing protein | - |
| J0G23_RS10390 (2107958) | 2107958..2108494 | - | 537 | WP_024229997.1 | GspM family type II secretion system protein YghD | - |
| J0G23_RS10395 (2108496) | 2108496..2109674 | - | 1179 | WP_024229998.1 | type II secretion system protein GspL | - |
| J0G23_RS10400 (2109671) | 2109671..2110648 | - | 978 | WP_000633199.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12194.91 Da Isoelectric Point: 6.4697
>T196097 WP_000854717.1 NZ_CP071263:2105618-2105944 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN
Download Length: 327 bp
>T196097 NZ_CP095021:362463-362888 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13533.31 Da Isoelectric Point: 5.0235
>AT196097 WP_001285644.1 NZ_CP071263:2105160-2105528 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT196097 NZ_CP095021:362245-362466 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|