Detailed information of TA system TA196072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4691410..4691926
• Replicon: chromosome
• Accession: NZ_CP071261
• Organism: Klebsiella pneumoniae strain MEI004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: J0G27_RS22750
• Protein ID: WP_004178374.1
• Coordinates: 4691410..4691694 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J0G27_RS22755
• Protein ID: WP_250354779.1
• Coordinates: 4691684..4691926 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0G27_RS22725 (4686806)	4686806..4687069	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
J0G27_RS22730 (4687199)	4687199..4687372	+	174	WP_040248667.1	hypothetical protein	-
J0G27_RS22735 (4687375)	4687375..4688118	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
J0G27_RS22740 (4688475)	4688475..4690613	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
J0G27_RS22745 (4690942)	4690942..4691406	+	465	WP_032418146.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
J0G27_RS22750 (4691410)	4691410..4691694	-	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J0G27_RS22755 (4691684)	4691684..4691926	-	243	WP_250354779.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J0G27_RS22760 (4692004)	4692004..4693914	-	1911	WP_004152270.1	PRD domain-containing protein	-
J0G27_RS22765 (4693937)	4693937..4695091	-	1155	WP_250354780.1	lactonase family protein	-
J0G27_RS22770 (4695158)	4695158..4695898	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T196072 WP_004178374.1 NZ_CP071261:c4691694-4691410 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T196072 NZ_CP095020:2319800-2320210 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT196072 WP_250354779.1 NZ_CP071261:c4691926-4691684 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT196072 NZ_CP095020:2319574-2319807 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Structures

Toxin

• AlphaFold DB: A6THG1