Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2449510..2450036 | Replicon | chromosome |
| Accession | NZ_CP071259 | ||
| Organism | Escherichia coli strain MEI005 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | J0G24_RS11915 | Protein ID | WP_000323025.1 |
| Coordinates | 2449749..2450036 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | J0G24_RS11910 | Protein ID | WP_000534858.1 |
| Coordinates | 2449510..2449749 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0G24_RS11880 (2444846) | 2444846..2445335 | + | 490 | Protein_2330 | class I SAM-dependent methyltransferase | - |
| J0G24_RS11885 (2445813) | 2445813..2446233 | + | 421 | Protein_2331 | hypothetical protein | - |
| J0G24_RS11890 (2446889) | 2446889..2447938 | + | 1050 | Protein_2332 | IS1202-like element ISEsa1 family transposase | - |
| J0G24_RS11895 (2448059) | 2448059..2448208 | + | 150 | WP_011443592.1 | protein YdfW | - |
| J0G24_RS11900 (2448645) | 2448645..2448977 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| J0G24_RS11905 (2449180) | 2449180..2449485 | - | 306 | WP_001326990.1 | protein YdfV | - |
| J0G24_RS11910 (2449510) | 2449510..2449749 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| J0G24_RS11915 (2449749) | 2449749..2450036 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| J0G24_RS11920 (2450108) | 2450108..2450263 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| J0G24_RS11925 (2450480) | 2450480..2450731 | + | 252 | WP_000980994.1 | protein Rem | - |
| J0G24_RS11930 (2450798) | 2450798..2451076 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| J0G24_RS11935 (2451078) | 2451078..2452127 | + | 1050 | WP_001439074.1 | DUF968 domain-containing protein | - |
| J0G24_RS11940 (2452141) | 2452141..2452893 | + | 753 | WP_001047135.1 | antitermination protein | - |
| J0G24_RS11945 (2453171) | 2453171..2453260 | - | 90 | WP_122985911.1 | hypothetical protein | - |
| J0G24_RS11950 (2453315) | 2453315..2453527 | - | 213 | WP_024172454.1 | cold shock-like protein CspF | - |
| J0G24_RS11955 (2453826) | 2453826..2454041 | + | 216 | WP_000066485.1 | cold shock-like protein CspB | - |
| J0G24_RS11960 (2454405) | 2454405..2454575 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| J0G24_RS11965 (2454794) | 2454794..2455009 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2436240..2489879 | 53639 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T196047 WP_000323025.1 NZ_CP071259:2449749-2450036 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T196047 NZ_CP095020:715175-715570 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT196047 WP_000534858.1 NZ_CP071259:2449510-2449749 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT196047 NZ_CP095020:714921-715175 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|