Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49342..50140 Replicon chromosome
Accession NZ_CP071259
Organism Escherichia coli strain MEI005

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag J0G24_RS00255 Protein ID WP_001609485.1
Coordinates 49342..49719 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag J0G24_RS00260 Protein ID WP_075370688.1
Coordinates 49766..50140 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G24_RS00225 (44699) 44699..45622 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
J0G24_RS00230 (45733) 45733..46916 - 1184 Protein_45 sugar efflux transporter -
J0G24_RS00235 (47313) 47313..47474 - 162 Protein_46 RhuM family protein -
J0G24_RS00240 (47708) 47708..48552 - 845 Protein_47 DUF4942 domain-containing protein -
J0G24_RS00245 (48648) 48648..48845 - 198 WP_001609487.1 DUF957 domain-containing protein -
J0G24_RS00250 (48857) 48857..49345 - 489 WP_001609486.1 DUF5983 family protein -
J0G24_RS00255 (49342) 49342..49719 - 378 WP_001609485.1 TA system toxin CbtA family protein Toxin
J0G24_RS00260 (49766) 49766..50140 - 375 WP_075370688.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J0G24_RS00265 (50303) 50303..50524 - 222 WP_000692323.1 DUF987 domain-containing protein -
J0G24_RS00270 (50593) 50593..51069 - 477 WP_001534813.1 RadC family protein -
J0G24_RS00275 (51084) 51084..51569 - 486 WP_000213697.1 antirestriction protein -
J0G24_RS00280 (51660) 51660..52478 - 819 WP_001175160.1 DUF932 domain-containing protein -
J0G24_RS00285 (52568) 52568..52801 - 234 WP_001278290.1 DUF905 family protein -
J0G24_RS00290 (52807) 52807..53484 - 678 WP_001097301.1 hypothetical protein -
J0G24_RS00295 (53632) 53632..54312 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.23 Da        Isoelectric Point: 7.2141

>T196031 WP_001609485.1 NZ_CP071259:c49719-49342 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYPEAKQ

Download         Length: 378 bp

>T196031 NZ_CP095011:c2616196-2615942 [Streptomyces sp. 2P-4]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTCGCCCGGAT
CAACAGGCTCATCGAGGACGTCAGGCGTGACCCCTTCACGGGTATCGGCAAGCCGGAGCCGCTGAAGTACCACCTGCCCG
GGGCGTGGTCGCGGCGGATCGACGATGAACACCGCCTCGTCTACCTGGTGACCGGCAAGGAGATCGTCATCCTCGCGGCC
CGGTACCGCTACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13681.46 Da        Isoelectric Point: 6.1991

>AT196031 WP_075370688.1 NZ_CP071259:c50140-49766 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDANVYPLDQAFPLLMKQLELMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Download         Length: 375 bp

>AT196031 NZ_CP095011:c2616468-2616193 [Streptomyces sp. 2P-4]
ATGTCGATAACTGCGAGCGAAGCCCGCAAGGAACTCTTTCCGCTGATCAAGAAGGTCAACGAGAACCACGAGGCCATTGA
GATCGTCTCCAAGCACGGCAACGCCGTACTTGTCTCGGCCGAGGACTATGCCGCGTTGCGTGAGGGCTCGTACCTGCTGC
GCTCCCCGGCGAACGCCCGTCGCTTGCTCAAGGCGTACGAGAACGCCCTGGCGAACATCAACGTGTCGGAGCGCGAGCTG
ATCGATCCTGACTCGGCGGACACGGGTGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References