Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4815473..4815989 Replicon chromosome
Accession NZ_CP071252
Organism Klebsiella pneumoniae strain MEI006

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag J0G26_RS23355 Protein ID WP_009486548.1
Coordinates 4815473..4815757 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J0G26_RS23360 Protein ID WP_002886901.1
Coordinates 4815747..4815989 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G26_RS23330 (4810890) 4810890..4811153 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
J0G26_RS23335 (4811283) 4811283..4811456 + 174 WP_002886906.1 hypothetical protein -
J0G26_RS23340 (4811459) 4811459..4812202 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J0G26_RS23345 (4812559) 4812559..4814697 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
J0G26_RS23350 (4815005) 4815005..4815469 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J0G26_RS23355 (4815473) 4815473..4815757 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J0G26_RS23360 (4815747) 4815747..4815989 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J0G26_RS23365 (4816067) 4816067..4817977 - 1911 WP_009486549.1 PRD domain-containing protein -
J0G26_RS23370 (4818000) 4818000..4819154 - 1155 WP_020316350.1 lactonase family protein -
J0G26_RS23375 (4819221) 4819221..4819961 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T196026 WP_009486548.1 NZ_CP071252:c4815757-4815473 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T196026 NZ_CP095000:c74431-74147 [Klebsiella michiganensis]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT196026 WP_002886901.1 NZ_CP071252:c4815989-4815747 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT196026 NZ_CP095000:c74669-74421 [Klebsiella michiganensis]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References