Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4075240..4075859 Replicon chromosome
Accession NZ_CP071252
Organism Klebsiella pneumoniae strain MEI006

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J0G26_RS19765 Protein ID WP_002892050.1
Coordinates 4075641..4075859 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J0G26_RS19760 Protein ID WP_002892066.1
Coordinates 4075240..4075614 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G26_RS19750 (4070392) 4070392..4071585 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J0G26_RS19755 (4071608) 4071608..4074754 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
J0G26_RS19760 (4075240) 4075240..4075614 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J0G26_RS19765 (4075641) 4075641..4075859 + 219 WP_002892050.1 HHA domain-containing protein Toxin
J0G26_RS19770 (4076018) 4076018..4076584 + 567 WP_002892030.1 maltose O-acetyltransferase -
J0G26_RS19775 (4076556) 4076556..4076696 - 141 WP_004147370.1 hypothetical protein -
J0G26_RS19780 (4076717) 4076717..4077187 + 471 WP_002892026.1 YlaC family protein -
J0G26_RS19785 (4077162) 4077162..4078612 - 1451 Protein_3892 PLP-dependent aminotransferase family protein -
J0G26_RS19790 (4078713) 4078713..4079411 + 699 WP_002892021.1 GNAT family protein -
J0G26_RS19795 (4079408) 4079408..4079548 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J0G26_RS19800 (4079548) 4079548..4079811 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T196024 WP_002892050.1 NZ_CP071252:4075641-4075859 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T196024 NZ_CP094999:c5370797-5370510 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAGGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTCTCGGCC
TCGTTCATGGGATCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT196024 WP_002892066.1 NZ_CP071252:4075240-4075614 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT196024 NZ_CP094999:c5370523-5370221 [Klebsiella michiganensis]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGATATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References