Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870613..871270 Replicon chromosome
Accession NZ_CP071252
Organism Klebsiella pneumoniae strain MEI006

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J0G26_RS04250 Protein ID WP_002916310.1
Coordinates 870860..871270 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J0G26_RS04245 Protein ID WP_002916312.1
Coordinates 870613..870879 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0G26_RS04220 (865769) 865769..867202 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
J0G26_RS04225 (867321) 867321..868049 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
J0G26_RS04230 (868099) 868099..868410 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J0G26_RS04235 (868574) 868574..869233 + 660 WP_002916317.1 hemolysin III family protein -
J0G26_RS04240 (869384) 869384..870367 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J0G26_RS04245 (870613) 870613..870879 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J0G26_RS04250 (870860) 870860..871270 + 411 WP_002916310.1 protein YgfX Toxin
J0G26_RS04255 (871277) 871277..871798 - 522 WP_002916308.1 flavodoxin FldB -
J0G26_RS04260 (871899) 871899..872795 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J0G26_RS04265 (872818) 872818..873531 + 714 WP_181244288.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J0G26_RS04270 (873537) 873537..875270 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T196014 WP_002916310.1 NZ_CP071252:870860-871270 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T196014 NZ_CP094999:40526-40867 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT196014 WP_002916312.1 NZ_CP071252:870613-870879 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT196014 NZ_CP094999:40877-41176 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References